A possible role for methotrexate in the treatment of childhood acute myeloid leukaemia, in particular for acute monocytic leukaemia

European Journal of Cancer

Volumn 37, Issue 4, 2001, Pages 492-498

  Rots, M G ^a   Pieters, R ^a,b   Jansen, G ^a   Kaspers, G J L ^a   Van Zantwijk, C H ^a   Noordhuis, P ^a   Voorn, D A ^a   Van Wering, E R ^c   Creutzig, U ^d   Veerman, A J P ^a   Peters, G J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c Dutch Childhood Leukemia Study Group   (Netherlands)

^d AML BFM Study Group   (Germany)

Author keywords

Acute monocytic leukaemia; Childhood acute myeloid leukaemia; Methotrexate; Polyglutamylation; Reduced folate carrier

Indexed keywords

METHOTREXATE; METHOTREXATE POLYGLUTAMATE; THYMIDYLATE SYNTHASE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MONOCYTIC LEUKEMIA; ARTICLE; CANCER RESISTANCE; CELL MEMBRANE TRANSPORT; CHILD; CHILDHOOD LEUKEMIA; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG EXPOSURE; DRUG SENSITIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; CHILD; DRUG RESISTANCE, NEOPLASM; HUMANS; LEUKEMIA, MONOCYTIC, ACUTE; METHOTREXATE; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED;

EID: 0035088009     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(00)00433-0     Document Type: Article

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