The spread of transgene expression at the site of gene construct injection

Muscle and Nerve

Volumn 24, Issue 4, 2001, Pages 488-495

  O'Hara, Amanda J ^a   McC Howell, John ^a   Taplin, Ross H ^a   Fletcher, Sue ^b   Lloyd, Frances ^a   Kakulas, Byron ^c   Lochmüller, Hanns ^d   Karpati, George ^a  

^a MURDOCH UNIVERSITY   (Australia)

^b PATHWEST LABORATORY MEDICINE   (Australia)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Duchenne muscular dystrophy; First generation adenovirus; Gene therapy; Golden retriever muscular dystrophy; Spread of expression

Indexed keywords

BETA GALACTOSIDASE; DYSTROPHIN; METHYLENE BLUE; VIRUS PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; FEMALE; GENE CONSTRUCT; GENE EXPRESSION; INJECTION SITE; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; TIBIALIS ANTERIOR MUSCLE; TRANSGENE;

ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; DISEASE MODELS, ANIMAL; DOGS; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; MALE; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, ANIMAL; PILOT PROJECTS; TISSUE DISTRIBUTION; TRANSGENES; VIRUS REPLICATION;

EID: 0035087291     PISSN: 0148639X     EISSN: None     Source Type: Journal    
DOI: 10.1002/mus.1031     Document Type: Article

References (14)

1. Human dystrophin expression in mdx mice after intramuscular injection of DNA constructs
2. A differential efficiency of adenovirus-mediated in vivo gene transfer into skeletal muscle cells of different maturity
3. Dystrophin expression in muscles of mdx mice after adenovirus-mediated in vivo gene transfer
4. Expression of a recombinant dystrophin in mdx mice using adenovirus vector
5. Persistence in muscle of an adenoviral vector that lacks all viral genes
6. In vivo muscle gene transfer of full-length dystrophin with an adenoviral vector that lacks all viral genes
7. Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector
8. Use of the dog model for Duchenne muscular dystrophy in gene therapy trials
9. High-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscle of dystrophic dogs: Prolongation of expression with immunosuppression
10. Direct dystrophin and reporter gene transfer into dog muscle in vivo
11. Emergence of early region 1-containing replication-competent adenovirus in stocks of replication-defective adenovirus recombinants (delta E1 + delta E3) during multiple passages in 293 cells
12. Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice
13. An error in dystrophin mRNA processing in golden retriever muscular dystrophy, an animal homologue of Duchenne muscular dystrophy
14. Direct gene transfer into mouse muscle in vivo