Endocrine regulation of G-protein subunit production in an animal model of type 2 diabetes mellitus

Journal of Endocrinology

Volumn 168, Issue 3, 2001, Pages 509-515

  Rodgers, B D ^a   Bernier, M ^a   Levine, M A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; FAT; GLUCOCORTICOID; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; ISOPROTEIN; PROTEIN SUBUNIT;

ADIPOCYTE MEMBRANE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LYSATE; CELL STIMULATION; CELL STRAIN 3T3; CONTROLLED STUDY; EPIDIDYMIS FAT; HORMONE ACTION; IMMUNOREACTIVITY; INSULIN RESISTANCE; MALE; METABOLIC DISORDER; MOLECULAR WEIGHT; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; STEROIDOGENESIS;

ADIPOCYTES; ANIMALS; BLOOD GLUCOSE; CELL CULTURE TECHNIQUES; CORTICOSTERONE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; EPIDIDYMIS; GTP-BINDING PROTEINS; INSULIN; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; PROTEIN ISOFORMS; TRIGLYCERIDES;

EID: 0035086468     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1680509     Document Type: Article

References (38)

1. Alpha-subunits of Gs and Gi in adipocyte plasma membranes of genetically diabetic (db/db) mice
2. Liver beta-adrenergic receptors, G proteins, and adenylyl cyclase activity in obesity-diabetes syndromes
3. Beta-adrenergic receptors and G-proteins in the ob/ob mouse
4. G-proteins in obesity
5. Body fat distribution, insulin resistance, and metabolic diseases
6. Visceral obesity and diabetes
7. Involvement of a pertussis-toxin-sensitive G protein in the induction of gene expression by insulin
8. Insulin action and the insulin signaling network
9. Signal-transducing G proteins: Basic and clinical implications
10. Repetitive segmental structure of the transducin beta subunit: Bomology with the CDC4 gene and identification of related mRNAs
11. Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning
12. Tissue-specific alterations in G protein expression in genetic versus diet-induced models of non-insulin-dependent diabetes mellitus in the mouse
13. Heterotrimeric G proteins
14. The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes
15. Animal models of diabetes and obesity, including the PBB/Ld mouse
16. G alpha-q/11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes
17. Identification, partial purification, and characterization of two guanosine triphosphate-binding proteins associated with insulin receptors
18. Insulin stimulates association of a 41 kDa G-protein (GIR41) with the insulin receptor
19. An insulin receptor peptide (1135-1156) stimulates guanosine 5′-[gamma-thio]triphosphate binding to the 67 kDa G-protein associated with the insulin receptor
20. 2
21. Influence of dietary carbohydrate on the induction of diabetes in C57BL/KsJ-db/db diabetes mice
22. Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide
23. 2
24. Heterotrimeric G proteins: Organizers of transmembrane signals
25. Hypercortisolism and obesity
26. Insulin affects the ability of Gi to be ADP-ribosylated but does not elicit its phosphorylation in intact hepatocytes
27. Role of heterotrimeric G-proteins in epidermal growth factor signalling
28. Adipocyte G-proteins and adenylate cyclase. Effects of adrenalectomy
29. Glucocorticoids modulate mRNA levels for G-protein beta-subunits
30. Diurnal rhythm for corticosterone in obese (ob/ob), diabetes (db/db) and gold-thioglucose-induced obesity in mice
31. Adrenalectomy and steroid treatment in obese (ob/ob) and diabetic (db/db) mice
32. Genetically acquired diabetes: Adipocyte guanine nucleotide regulatory protein expression and adenylate cyclase regulation
33. Alterations in G-protein expression and the hormonal regulation of adenylate cyclase in the adipocytes of obese (fa/fa) Zucker rats
34. Regulation of cardiac adenylate cyclase activity in rodent models of obesity
35. A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C
36. Diversity among the beta subunits of heterotrimeric GTP-binding proteins: Characterization of a novel beta-subunit cDNA
37. 2 in vivo ameliorates streptozotocin-induced diabetes