Cannabinoid inhibition of the capsaicin-induced calcium response in rat dorsal root ganglion neurones

British Journal of Pharmacology

Volumn 132, Issue 5, 2001, Pages 969-971

  Millns, P J ^a   Chapman, V ^a   Kendall, D A ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Cannabinoids; Dorsal root ganglion neurones; Vanilloids

Indexed keywords

CANNABINOID; CANNABINOID 1 RECEPTOR; CAPSAICIN; DEXANABINOL; RIMONABANT; VANILLOID RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SOMATOSENSORY SYSTEM; SPINAL GANGLION;

EID: 0035081251     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703919     Document Type: Article

References (14)

1. Inhibition of receptor-mediated calcium responses by corticotrophin-releasing hormone in the CATH.a cell line
2. Bidirectional control of airway responsiveness by endogenous cannabinoids
3. The capsaicin receptor: A heat-activated ion channel in the pain pathway
4. 35S]GTPγS binding in the dorsal horn of the spinal cord of inflamed and non-inflamed rats
5. Cannabinoid CB(1) receptor expression in rat spinal cord
6. Spinal anandamide inhibits nociceptive transmission via eannabinoid receptor activation in vivo
7. Capsaicin sensitivity is associated with the expression of the vanilloid (eapsaiein) receptor (VR1) mRNA in adult rat sensory ganglia
8. Cannabinoid receptors undergo axonal flow in sensory nerves
9. Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons
10. A study of the voltage dependence of capsaicin-activated membrane currents in rat sensory neurones before and after acute desensitization
11. Vanilloid receptors on capsaicin-sensitive sensory nerves mediate relaxation to methanandamide in the rat isolated mesenteric arterial bed and small mesenteric arteries
12. Characterization of two cloned human CB1 cannabinoid receptor isoforms
13. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
14. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide