Lack of HLA-class I antigens in human neuroblastoma cells: Analysis of its relationship to TAP and tapasin expression

Tissue Antigens

Volumn 57, Issue 2, 2001, Pages 110-117

  Corrias, M V ^a   Occhino, M ^a   Croce, M ^b   De Ambrosis, A ^b   Pistillo, M P ^b   Bocca, P ^a   Pistoia, V ^a   Ferrini, S ^b,c  

^a G GASLINI INSTITUTE   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

HLA class I; Interferon ; Neuroblastoma; TAP; Tapasin

Indexed keywords

BETA 2 MICROGLOBULIN; GAMMA INTERFERON; HLA ANTIGEN; HLA ANTIGEN CLASS 1; MESSENGER RNA; RECOMBINANT GAMMA INTERFERON; TAPASIN;

ANTIGEN PRESENTATION; ARTICLE; CHROMOSOME DELETION; GENE AMPLIFICATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MUTATION; NEUROBLASTOMA; NORTHERN BLOTTING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANTIGENS, SURFACE; ANTINEOPLASTIC AGENTS; ANTIPORTERS; ATP-BINDING CASSETTE TRANSPORTERS; BETA 2-MICROGLOBULIN; BLOTTING, WESTERN; BRAIN NEOPLASMS; EXTRACELLULAR MATRIX PROTEINS; GENE DELETION; GENE EXPRESSION; GENES, MYC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULINS; INTERFERON TYPE II; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; NEUROBLASTOMA; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0035076824     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0039.2001.057002110.x     Document Type: Article

References (40)

1. Transporter associated with antigen processing
2. Genes regulating MHC class I processing of antigen
3. TAP association influences the conformation of nascent MHC class I molecules
4. The N-terminal region of tapasin is required to stabilize the MHC class I loading complex
5. Peptide-bound major histocompatibility complex class I molecules associate with tapasin before dissociation from transporter associated with antigen processing
6. Implications for immunosurveillance of altered HLA class I phenotypes in human tumours
7. Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in β-2m gene expression
8. Identification of human cancers deficient in antigen processing
9. MHC regulation in neural cells. Distribution of peripheral and internal beta 2-microglobulin and class I molecules in human neuroblastoma cell lines
10. Repression of class I H-2K, H-2D antigens on GR9 methylcholanthrene-induced tumour cell clones is related to the level of DNA methylation
11. Antigen presentation by MHC class I and its regulation by interferon-γ
12. Interferon-mediated induction of class I MHC products in human neuronal cell lines: Analysis of HLA and beta-2 mRNA, and HLA-A and HLA-B proteins and polymorphic specificities
13. Uncoordinate induction and differential regulation of HLA class-I and class-II expression by γ-interferon in differentiating human neuroblastoma cells
14. IFN-γ gene transfer restores HLA-class I expression and MAGE-3 antigen presentation to CTL in HLA-deficient small cell lung cancer
15. Transfection of TAP 1 gene restores HLA class I expression in human small-cell lung carcinoma
16. Weak HLA and beta 2-microglobulin expression of neuronal cell lines can be modulated by interferon
17. MYC-N amplification causes down-modulation of MHC class I antigen expression in neuroblastoma
18. In vitro modulation and relationship between MYC-N and HLA class I RNA steady-state levels in human neuroblastoma cells
19. Altered growth and phenotype in clonal MYC-N transfectants of the SK-N-SH neuroblastoma cell line
20. Active repression of major histocompatibility complex class I genes in a human neuroblastoma cell line
21. Suppression of MHC class I gene expression by MYC-N through enhancer inactivation
22. Regulation of MHC class I and beta 2-microglobulin gene expression in human neuronal cells. Factor binding to conserved cis-acting regulatory sequences correlates with expression of the genes
23. Beta 2-microglobulin expression in human embryonal neuroblastoma reflects its developmental regulation
24. Lack of class I HLA expression in neuroblastoma is associated with high MYC-N expression and hypomethylation due to loss of the MEMO-1 locus
25. A human modifer of methylation for class I HLA genes (MEMO-1) maps to chromosomal bands 1p35-36.1
26. Kinetically coordinated induction of TAP-1 and HLA class I by IFN-γ: The rapid induction of TAP-1by IFN-γ is mediated by stat 1 alpha
27. Genomic analysis of the tapasin gene, located close to the TAP loci in the MHC
28. Expression of MAGE genes by non-small-cell lung carcinomas
29. 2-m-free HLA-B and -C heavy chains
30. Heterogeneous distribution of determinants defined by monoclonal antibodies on HLA-A, -B antigen bearing molecules
31. Biochemical analysis of HLA class I subunits expression in breast cancer tissues
32. Biosynthesis of HLA-C heavy chains in melanoma cells with multiple defects in the expression of HLA-A, -B, -C molecules
33. Nucleotide binding to the hydrophylic C-terminal domain of the transporter associated with antigen processing (TAP)
34. Neuroblastoma
35. Effect of 5-azacytidine on differentiation and DNA methylation in human promyelocytic leukemia cells (HL-60)
36. A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity
37. Expression of beta 2m-free HLA class I heavy chains in neuroblastoma cell lines
38. Soluble β2-microglobulin-free class I heavy chain are released from the surface of activated and leukemia cells by a metalloprotease
39. Secretion of HLA-A and -B antigens via an alternative RNA splicing pathway
40. Prolonged upregulation of the expresssion of HLA class I antigens and costimulatory molecules on melanoma cells treated with 5-aza-2′-deoxycytidine (5-AZA-CdR)