Dynamic changes of connexin-43, gap junctional protein, in outer layers of cumulus cells are regulated by PKC and PI 3-kinase during meiotic resumption in porcine oocytes

Biology of Reproduction

Volumn 64, Issue 4, 2001, Pages 1255-1263

  Shimada, M ^a   Maeda, T ^a   Terada, T ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Cumulus cells; Kinases; Meiosis; Ovum; Signal transduction

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CALPHOSTIN C; CONNEXIN 43; GAP JUNCTION PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; UO 126;

ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL NUCLEUS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; IMMUNOFLUORESCENCE TEST; NONHUMAN; OOCYTE DEVELOPMENT; OVARY FOLLICLE CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; REGULATORY MECHANISM; SWINE;

ANIMALIA; MAMMALIA; SUIDAE; SUS SCROFA;

EID: 0035076762     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod64.4.1255     Document Type: Article

References (32)

1. Cyclic adenosine monophosphate and ovarian follicular fluid act synergistically to inhibit mouse oocyte maturation
2. Maintenance of murine oocyte meiotic arrest: Uptake and metabolism of hypoxanthine and adenosine by cumulus cell-enclosed and denuded oocytes
3. Cumulus cells suppress meiotic progression in pig oocytes cultured in vitro
4. A dramatic loss of cumulus cell gap junctions is correlated with germinal vesicle breakdown in rat oocytes
5. Differential modulation of rat follicle cell gap junction populations at ovulation
6. Involvement of meiotic resumption in the disruption of gap junctions between cumulus cells attached to pig oocytes
7. Gap junctions in the ovaries
8. Differential expression of four connexin genes, Cx-26, Cx-30.3, Cx-32 and Cx-43, in the porcine ovarian follicle
9. Isolation and characterization of a novel connexin gene, Cx-60, in the porcine ovarian follicles
10. Differential phosphorylation of the gap junction protein connexin 43 in junctional communication-competent and -deficient cell lines
11. Regulation of connexin 43 function by activated tyrosine protein kinases
12. Lysophosphatidic acid inhibits gap-junctional communication and stimulates phosphorylation of connexin-43 in WB cells: Possible involvement of the mitogen-activated protein kinase cascade
13. Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein
14. Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways
15. Effects of phosphatidylinositol 3kinase inhibitors, wortmannin and LY294002, on germinal vesicle breakdown (GVBD) in porcine oocytes
16. Phosphorylation of connexin-43, gap junctional protein, in cumulus cells is regulated by mitogen-activated arotein ainase and phosphatidylinositol 3-kinase during in vitro meiotic resumption in porcine follicular oocytes
17. Phosphorylation and expression of connexin-43 ovarian gap junction protein are regulated by luteinizing hormone
18. Addition of taurine or hypotaurine to culture medium improves development of one- and two-cell pig embryos in vitro
19. Breakdown of the germinal vesicle in pig oocytes in vivo and in vitro
20. Cleavage of structural proteins during the assembly of the heat of bacteriophage T4
21. Effects of wortmannin on the kinetics of GVBD and the activities of the maturation-promoting factor and mitogen-activated protein kinase during bovine oocyte maturation in vitro
22. Effect of aging on parthenogenetic activation with cycloheximide and alteration of the activity of maturation promoting factor during aging of bovine oocytes
23. Cyclic AMP in mammalian follicle cells and oocytes during maturation
24. Transcription of the gene for the gap junctional protein connexin 43 and expression of functional cellto-cell channels are regulated by cAMP
25. Human granulosa cells in culture exhibit functional cyclic AMP-regulated gap junction
26. The relationship between cumulus-oocyte coupling, oocyte meiotic maturation, and cumulus expansion
27. Insulin-stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway
28. Growth hormone stimulates phosphorylation and activation of Elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinase 1 and 2
29. Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1
30. Effects of α-amanitin on nuclear maturation of porcine oocytes in vitro
31. Changes in intercellular coupling between pig oocytes and cumulus cells during maturation in vivo and in vitro
32. Changes in dye coupling and physical integrity between oocyte and cumulus cells during oocyte maturation in mice