Effect of the antianginal drug bepridil on intracellular Ca2+ release and extracellular Ca2+ influx in human neutrophils

International Immunopharmacology

Volumn 1, Issue 5, 2001, Pages 945-953

  Chen, Lee Wei ^a,b   Jan, Chung Ren ^a,c  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Bepridil; Ca2+ movement; Fura 2; Neutrophil; Protein kinase C

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; BEPRIDIL; FURA 2; PROTEIN KINASE C; THAPSIGARGIN;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NEUTROPHIL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANGINA PECTORIS; BEPRIDIL; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; ESTRENES; HUMANS; ION TRANSPORT; NEUTROPHILS; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASE C; PROTEIN KINASE C; PYRROLIDINONES; REACTIVE OXYGEN SPECIES;

EID: 0035076025     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(01)00031-5     Document Type: Article

References (33)

1. Pharmacology of bepridil
2. A review of its pharmacological properties and therapeutic use in stable angina pectoris
3. Mechanism of inhibition of the sodium current by bepridil in guinea-pig isolated ventricular cells
4. Block of Na+ channel by bepridil in isolated guinea-pig ventricular myocytes
5. Block of cardiac sodium-calcium exchange by mechanism-based inhibitors
6. pH-dependent effects of bepridil on Ca2+-extrusion across rat heart sarcolemma
7. Blockade of myocardial slow channels by bepridil (CERM-1978)
8. Bepridil block of cardiac calcium and sodium channels
9. Bepridil hydrochloride alters potential-dependent and receptor-operated calcium channels in vascular smooth muscle of rabbit aorta
10. Blockade of bepridil on IA and IK in acutely isolated hippocampal CA1 neurons
11. Calcium channel antagonists induce direct inhibition of the outward rectifying potassium channel in tobacco protoplasts
12. Inhibition of sodium pump by bepridil. An in vitro and microcalorimetric study
13. Bepridil-induced blockade of NMDA channels in rat hippocampal neurones
14. Effect of bepridil on intracellular calcium concentration and contraction in cultured rat ventricular myocytes
15. L-selectin stimulation of canine neutrophil initiates calcium signal secondary to tyrosine kinase activation
16. Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart
17. Neutrophils, host defense, and inflammation: A double-edged sword
18. Leukocyte-endothelial adhesion molecules
19. Calcium signaling
20. Platelet-activating factor induces a concentration-dependent spectrum of functional responses in bovine neutrophils
21. Mechanisms of IL-8-induced Ca2+ signaling in human neutrophil granulocytes
22. The signal for capacitative calcium entry
23. Extracellular Ca2+ regulates the respiratory burst of human neutrophils
24. Oxidase activation in individual neutrophils is dependent on the onset and magnitude of the Ca2+ signal
25. A new generation of Ca2+ indicators with greatly improved fluorescence properties
26. Flow cytometric analysis of the granulocyte respiratory burst: A comparison study of fluorescent probes
27. Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase
28. Propionic acid stimulates superoxide generation in human neutrophils
29. Pharmacokinetics of intravenous bepridil in patients with coronary disease
30. 2+ signaling in neutrophils by the mast cell-released immunophilin FKBP12
31. 2+ stores
32. Involvement of tyrosine kinases, Ca2+ and PKC in activation of mitogen- activated protein (MAP) kinase in human polymorphonuclear neutrophils
33. Identification and regulation of protein kinase C-delta in human neutrophils