Effect of bile acids on billiary excretion of cyclosporin A in the rat

Hepatology Research

Volumn 20, Issue 1, 2001, Pages 128-132

  Takikawa, Hajime ^a   Sano, Naoyo ^a   Takada, Yukiko ^a   Toda, Atsuko ^a   Tanaka, Hiroyuki ^a   Takamori, Yoriyuki ^a  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bile acids; Cholestasis; Cyclosporin A; P glycoprotein

Indexed keywords

BILE ACID; CYCLOSPORIN A; GLYCOPROTEIN P; TAUROCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE FLOW; CHOLESTASIS; CONTROLLED STUDY; DRUG BILE LEVEL; ENZYME SUBSTRATE; INFUSION; INTRAHEPATIC BILE DUCT; MALE; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0035075644     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(00)00126-1     Document Type: Article

References (15)

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4. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
5. The sister of pglycoprotein represents the canalicular bile salt export pump of mammalian liver
6. Human P-glycoprotein transports cyclosporin A and FK506
7. Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane
8. Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver
9. Improvement of cyclosporin A-induced cholestasis by tauroursodeoxychol ate in a long-term study in the rat
10. Up-regulation of the multidrug resistance genes, Mrp. 1 and Mdrlb, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, of endotoxemic rat liver
11. Changes in the localization of the rat canalicular conjugate export pump Mrp 2 in phalloidin-induced cholestasis
12. Bile acid secretion and direct targeting of mdrl-green fluorescent protein from Golgi to the canalicular membrane in polarized WIF-B cells
13. Tubulovesicular transcytotic pathway in isolated rat hepatocyte couplets in culture. Effect of colchicine and taurocholate
14. Taurocholate stimulates transcytotic vesicular pathways labeled by horseradish peroxidase in the isolated perfused liver
15. Tubulovesicular transport of horseradish peroxidase in isolated rat hepatocyte couplets: Effects of low temperature, cytochalasin B and bile acids