Toxicological, medical and industrial hygiene aspects of glutaraldehyde with particular reference to its biocidal use in cold sterilization procedures

Journal of Applied Toxicology

Volumn 21, Issue 2, 2001, Pages 131-151

  Ballantyne, Bryan ^a   Jordan, Susan L ^a  

^a UNION CARBIDE CORPORATION   (United States)

Author keywords

Acute toxicity; Carcinogenicity; Chronic toxicity; Development toxicity; Eye irritation; Genotoxicity; Glutaraldehyde; Metabolism, human studies; Pharmacokinetics; Phototoxicity; Protective Measures; Reproductive toxicity; Respiratory sensitization; Sensory irritation; Skin irritation; Skin sensitization; Subchronic toxicity

Indexed keywords

DNA; GLUTARALDEHYDE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; SOLVENT;

AIRBORNE PARTICLE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ASTHMA; BACTERIAL MUTATION; BONE MARROW CELL; BREATHING RATE; CARCINOGENICITY; CELL NUCLEUS; CHROMOSOME ABERRATION; CHRONIC TOXICITY; COLD EXPOSURE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONJUNCTIVA; CONTAMINATION; CONTROL SYSTEM; CONTROLLED STUDY; CORNEA INJURY; CORROSION; DEVELOPMENTAL BIOLOGY; DISEASE SEVERITY; DNA REPAIR; DOMINANT LETHAL TEST; DROSOPHILA; ENDOSCOPE; ENGINEERING; ERYTHEMA; EXPOSURE; EYE INJURY; EYE IRRITATION; EYE PROTECTION; FEMALE; FLUID INTAKE; GENE MUTATION; GENOTOXICITY; HAZARD; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INCIDENCE; INDUSTRIAL HYGIENE; INFLAMMATION; INSTRUMENT STERILIZATION; KIDNEY; LARGE GRANULAR LYMPHOCYTE; LYMPHATIC LEUKEMIA; MATERIALS HANDLING; MAXIMUM ALLOWABLE CONCENTRATION; MEDICAL INSTRUMENTATION; MEDICINE; MOUSE; MOUTH; MUTAGENICITY; NEOPLASM; NONHUMAN; NOSE CAVITY; NOSE MUCOSA; OCCUPATIONAL EXPOSURE; PERITONEUM; PHARMACOKINETICS; PHOTOSENSITIVITY; PHOTOTOXICITY; PHYLOGENY; PRIORITY JOURNAL; PROTECTION; RAT; REPRODUCTION; RESPIRATORY TRACT INJURY; REVIEW; SAFETY; SISTER CHROMATID EXCHANGE; SKIN EDEMA; SKIN IRRITATION; SKIN PENETRATION; SKIN PROTECTION; SKIN SENSITIZATION; SKIN TOXICITY; TARGET ORGAN; TEMPERATURE; TERATOGENICITY; TIME; TOXICITY; TOXICOLOGY; TRAINING; VAPOR;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; DISINFECTANTS; DNA DAMAGE; DRUG HYPERSENSITIVITY; EQUIPMENT AND SUPPLIES; EQUIPMENT CONTAMINATION; FEMALE; GLUTARAL; MALE; MICE; OCCUPATIONAL EXPOSURE; PERIPHERAL NERVOUS SYSTEM; RABBITS; RATS; RESPIRATORY SYSTEM; SKIN; VOLATILIZATION;

BACTERIA (MICROORGANISMS);

EID: 0035075477     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.741     Document Type: Review

References (168)

1. Disinfection and sterilization in dentistry
2. Gastrointestinal endoscopy: Infection and disinfection
3. Glutaraldehyde: Current status and uses
4. Cleaning and disinfection of equipment for gastrointestinal flexible endoscopy: Interim recommendations of a Working Party of the British Society of Gastroenterology
5. Relationship between pH and antibacterial activity of glutaraldehyde
6. The state of the glutaraldehyde molecule in relation to its biocidal activity
7. Toxicology of Glutaraldehyde
8. Final report on the safety assessment of glutaraldehyde
9. Toxicity Profile: Glutaraldehyde
10. Ecotoxicology of Glutaraldehyde
11. The vapor pressure of pure and aqueous glutaraldehyde
12. Structure of aqueous glutaraldehyde
13. The acute toxicity and primary irritancy of glutaraldehyde
14. Influence of alkalinization of glutaraldehyde biocidal solutions on acute toxicity, primary irritancy and skin sensitization
15. Comparative acute toxicity, irritancy, and skin sensitization of unbuffered and buffered glutaraldehyde (GA)
16. Dermal sensitizing potential of glutaraldehyde; a review and recent observations
17. Topical glutaraldehyde for palmar hyperhydrosis
18. Topical glutaraldehyde-percutaneous penetration, skin irritation
19. Cutaneous necrosis induced by application of a 20% solution of glutaraldehyde on a wart
20. Toxic eye injury during induction of anesthesia
21. Glutaraldehyde keratopathy
22. Development and validation of an alternative dermal sensitization test: The mouse ear swelling test (MEST)
23. Identification of contact allergies: The mouse ear swelling assay
24. Evaluation of several variations of the mouse ear swelling test (MEST) for detection of weak and moderate contact allergens
25. Evaluation of relative skin sensitizing potential using the local lymph node assay: A comparison of formaldehyde with glutaraldehyde
26. Comparison of cytokine secretion profiles provoked in mice by glutaraldehyde and formaldehyde
27. Contact hypersensitivity response to glutaraldehyde in guinea pigs and mice
28. Allergic contact dermatitis due to Cidex
29. Glutaraldehyde contact dermatitis
30. Contact dermatitis from glutaraldehyde
31. Glutaraldehyde and formaldehyde allergy
32. Contact dermatitis due to sensitivity to Cidex (activated glutaraldehyde)
33. Occupational allergic contact dermatitis due to glutaraldehyde
34. Allergic contact dermatitis from glutaraldehyde exposure
35. Hyperhydrosis: Treatment with glutaraldehyde
36. Buffered glutaraldehyde solution for warts
37. Pitted keratolysis forme fruste: A review and new therapies
38. Treatment of superficial onychomycosis with topically applied glutaraldehyde
39. Localized epidermolysis bullosa. Report of two cases and evaluation of therapy with glutaraldehyde
40. Herpes zoster and herpes simplex. Local therapy with glutaraldehyde
41. Eccrine anhydrosis due to glutaraldehyde, formaldehyde and iontophoresis
42. The use of graded concentrations in studying skin sensitizers: Experimental contact sensitization in man
43. Glutaraldehyde (Pentanedial) allergic contact dermatitis
44. Glutaraldehyde: Cross reactions to formaldehyde
45. Evaluation of antigenic determinant in glutaraldehyde contact dermatitis by patch testing with chemically related substances
46. Peripheral sensory irritation: Basics and applications
47. Concentration-dependent immunologic response to toluence diisocyanate (TDI) following inhalation exposure
48. Respiratory peripheral sensory irritation and hypersensitivity studies with glutaraldehyde vapor
49. Establishing threshold limit values for airborne sensory irritants from an animal model and the mechanism of action of sensory irritants
50. Nasal and pulmonary toxicity of glutaraldehyde in mice
51. Human Sensory Irritation Threshold of Glutaraldehyde Vapor
52. Four-week repeated skin contact study with glutaraldehyde
53. Clinical pathologic changes related to cutaneous irritation in the Fischer 344 rat and New Zealand white rabbit
54. Subchronic peroral toxicity of glutaraldehyde to the mouse, rat and dog
55. Subchronic inhalation toxicity of glutaraldehyde
56. Histopathological studies in B6C3F1 mice chronically exposed by inhalation to glutaraldehyde
57. Combined chronic toxicity/oncogenicity study with glutaraldehyde (GA) in the drinking water of rats
58. Pathology of the mononuclear cell leukemia of Fischer rats. II. Hematology
59. The early stage of large granular lymphocytic leukemia in the F344 rat
60. Large granular lymphocyte leukemia in Fischer 344 (F344) rats: Summary of incidence from several laboratories
61. Spleen, lymph nodes and thymus
62. Effects of glutaraldehyde in a 2-year inhalation study in rats and mice
63. DNA repair test of disinfectants by liquid rec-assay
64. Salmonella mutagenicity test results for 250 chemicals
65. A new Salmonella tester strain (TA102) with A.T bases at the site of mutation detects oxidative mutagens
66. Collaborative study of mutagenicity with Salmonella typhimurium TA102
67. Comparison of Salmonella typhimurium TA102 with Escherichia coli WP2 tester strains
68. Naturally occurring carbinyl compounds are mutagens in Salmonella tester strain 104
69. The evaluation of genotoxic activities of disinfectants and their metabolities by UMU test
70. Oxidative mutagens specific for AT base pairs induce forward mutations to L-arabinase resistance in Salmonella typhimurium
71. Comparison of alkylation rates and mutagenicity of directly acting industrial and laboratory chemicals
72. New forward mutation assay using low-concentration streptomycin resistance mutation in E. coli strains with plasmid pKM101
73. Evaluation of the SOS chromotest
74. Evaluation of the genotoxic potential of glutaraldehyde
75. - mouse lymptoma cell forward mutation assay. II. 18 coded chemicals
76. Development of a standard protocol for in vivo cytogenetic testing with Chinese Hamster ovary cells; comparison of results for 22 compounds in two laboratories
77. Measurement of unscheduled DNA synthesis and S-phase synthesis in rodent hepatocytes following in vivo treatment; testing of 24 compounds
78. Mutagenicity of glutaraldehyde in mice
79. Chemical mutagenesis testing in Drosiphila IV. Results of 45 coded compounds tested for the National Toxicology Program
80. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments
81. Subcellular localization of glutaraldehyde
82. Influence of formaldehyde and Sonacide (potentiated acid glutaraldehyde) in embryo and fetal development in mice
83. Teratological assessment of glutaraldehyde in rats by gastric intubation
84. Two-generation reproduction study with glutaraldehyde (GA) in the drinking water of CD rats
85. Two generation reproduction study by dosing with glutaraldehyde in drinking water of CD rats
86. Spontaneous abortion in hospital staff engaged in sterilizing instruments with chemical agents
87. Spontaneous abortions and malformations in the offspring of nurses exposed to anesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcomes
88. Percutaneous pharmacokinetics and material balance studies with glutaraldehyde
89. Glutaraldehyde; species comparisons of in vitro skin penetration
90. Energy linked oxidation of glutaraldehyde by rat liver mitrochondria
91. 14C-glutaraldehyde from glutaraldehyde-treated pulpotomy sites
92. Subcellular localization of glutaraldehyde
93. The oxidation of glutaraldehyde by rat tissues
94. Toxicology of glutaraldehyde: A critical review
95. Metabolism of malondialdehyde by rat liver aldehyde dehydrogenase
96. Aldehyde oxidizing enzymes
97. Mammalian metabolism of glutaric acid
98. Exposure of formaldehyde and glutaraldehyde in operating theatres
99. Occupational health problems in processing x-ray photographic films
100. Skin and respiratory symptoms from exposure to alkaline glutaraldehyde in medical services
101. Occupational hazard in staff exposed to 2 percent glutaraldehyde in an endoscopy unit
102. Report, Symptoms of irritation associated with exposure to glutaraldehyde-Colorado
103. Epistaxis due to glutaraldehyde exposure
104. Allergic contact dermatitis from glutaraldehyde exposure
105. Case report: Exposure to glutaraldehyde
106. Asthma and rhinitis after exposure to glutaraldehyde in endoscopy units
107. Occupational asthma in radiographers
108. Glutaraldehyde allergy in hospital workers
109. Glutaraldehyde allergy in endoscopy units
110. Occupational asthma in a technologist exposed to glutaraldehyde
111. Occupational asthma due to glutaraldehyde and formaldehyde in endoscopy and x-ray departments
112. Clinical and immunologic evaluation of workers exposed to glutaraldehyde
113. Occupational asthma due to glutaraldehyde
114. Glutaraldehyde an occupational hazard in the hospital setting
115. Glutaraldehyde, asthma and work - A continuing tale
116. Work-related late asthmatic response induced by latex allergy
117. Occupational asthma due to latex in a hospital administration employee
118. Latex allergy
119. Latex sensitization: Occupational versus general population persistence rates
120. Absences of sensitizations and cancer increases among glutaraldehyde workers
121. Glutaraldehyde exposures and symptoms among endoscopy nurses in South Australia
122. Survey of symptoms, respiratory function, immunology in endoscopy nursing staff and their relationship to glutaraldehyde and other occupational exposures
123. CT findings of glutaraldehyde colitis: A report of two cases
124. Endoscope-induced colitis: Description, probable cause by glutaraldehyde, and prevention
125. Post-colonoscopy chemical proctitis
126. Glutaraldehyde-induced proctitis after endorectal ultrasound examination: A higher risk of incidence than expected
127. Glutaraldehyde as a possible cause of diarrhea after sigmoidoscopy
128. Glutaraldehyde colitis: Radiologic findings
129. Acute hemorrhagic colitis induced by glutaraldehyde after colonoscopy
130. Rectitis after colonoscopy
131. Investigation of an outbreak of bloody diarrheas association with endoscopic cleaning solution and demonstration of lesions in animal model
132. Chemical colitis due to endoscopy cleaning solutions: A mimic of pseudomenbranous colitis
133. Outbreak of glutaraldehyde-induced proctocolitis
134. Cidex-induced synovitis
135. Glutaraldehyde-induced esophageal injury. Histologic study of laboratory rats
136. An epidemic of pseudomembranous laryngotracheitis
137. Glutaraldehyde permeation: Choosing the proper glove
138. Penetration of glutaraldehyde through glove material: Tactylonversus natural rubber latex
139. The correct use of glutaraldehyde in the healthcare environment
140. Laboratory and hospital evaluation of four personal monitoring methods for glutaraldehyde in ambient air
141. Exposure to glutaraldehyde vapors during endoscopic sterilization processes in a large research and teaching institution
142. Respiratory Protection. Principles and Applications
143. Inactivation of glutaraldehyde by reaction with sodium bisulfite
144. Cleaning and disinfection of fiberoptic endoscopes: Activation of glutaraldehyde exposure time and forced-air drying
145. Disinfectant colitis
146. Aldehyde disinfectants and health in endoscopy units