Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4

Cellular Signalling

Volumn 13, Issue 4, 2001, Pages 287-297

  Richter, Wito ^a   Unciuleac, Liviu ^a   Hermsdorf, Thomas ^a   Kronbach, Thomas ^b   Dettmer, Dietrich ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b ASTA MEDICA AG   (Germany)

Author keywords

Cyclic AMP phosphodiesterase; Inhibitor; Inhibitor binding sites; Mutagenesis; PDE4; Pharmacophor; Phosphodiesterase

Indexed keywords

8 METHOXY 5 N PROPYL 3 METHYL 1 ETHYLIMIDAZO[1,5 A]PYRIDO[3,2 E]PYRAZINONE; AROFYLLINE; AWD 12281; COMPLEMENTARY DNA; CYCLIC AMP PHOSPHODIESTERASE; D 22888; N (3,5 DICHLORPYRID 4 YL) [1 (4 FLUORBENZYL) 5 HYDROXYINDOL 3 YL]GLYOXYLATEAMIDE; PHOSPHODIESTERASE INHIBITOR; PICLAMILAST; PLASMID DNA; ROLIPRAM; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DELETION MUTANT; DRUG BINDING SITE; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; MUTAGENESIS; POINT MUTATION; PRIORITY JOURNAL; SECOND MESSENGER; SIDE EFFECT; SITE DIRECTED MUTAGENESIS;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; BINDING SITES; BLOTTING, WESTERN; COS CELLS; CYCLIC AMP; DRUG DESIGN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; GENE DELETION; HISTIDINE; HUMANS; INHIBITORY CONCENTRATION 50; IONS; KINETICS; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHENYLALANINE; PHOSPHODIESTERASE INHIBITORS; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; ROLIPRAM; TRYPTOPHAN; TYROSINE; ZINC;

EMESIS;

EID: 0035073963     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0898-6568(01)00150-4     Document Type: Article

References (47)