The effects of milling upon the physicochemical properties and functional behavior of some disintegrants

S.T.P. Pharma Sciences

Volumn 11, Issue 2, 2001, Pages 123-128

  Thibert, R ^a   Hancock, B C ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Disintegrants; Disintegration time; Functional aspects; Hardness; Milling; Physicochemical properties

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; CROSCARMELLOSE SODIUM; CROSPOVIDONE; DISINTEGRATING AGENT; LACTOSE; POVIDONE; STARCH GLYCOLATE SODIUM; SUPER TAB;

ARTICLE; DRUG MIXTURE; MOISTURE; PARTICLE SIZE; TABLET COMPRESSION; TABLET DISINTEGRATION TIME; TABLET FORMULATION; TABLET HARDNESS; TABLET SURFACE; WATER ABSORPTION;

EID: 0035073706     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Studies on direct compression of tablets. Part 4: Effect of particle size on the mechanical strength of tablet
2. Mixing of pharmaceutical solids. 1. Effect of particle size on mixing in cylindrical shear and V-shaped tumbling mixers
3. The effect of particle size on the granulation of lactose by massing and screening
4. The effect of particle size and moisture on the tensile strength of microcrystalline cellulose
5. Particle size effects on the dehydration of dicalcium phosphate dihydrate powders
6. Direct visualization of superdisintegrant hydration using environmental scanning electron microscopy
7. Effect of compressional force on tablets containing cellulosic disintegrators. I. Dimensionless disintegration values
8. Crystallinity and physical characteristics of microcrystalline cellulose
9. Effect of crystallinity of microcrystalline cellulose on granulation in high-shear mixer