The intestinal mucus protects poly(isobutylcyanoacrylate) nanoparticles from enzymatic degradation

S.T.P. Pharma Sciences

Volumn 11, Issue 2, 2001, Pages 175-180

  Dembri, A ^a   Duchene D ^a   Ponchel, G ^a  

^a UNIV PARIS SUD   (France)

Author keywords

Degradation; Esterase; Gastro intestinal tract; Mucus; Nanoparticles; Oral route; Poly(isobutylcyanoacrylate)

Indexed keywords

DRUG CARRIER; ESTERASE; NANOPARTICLE; POLY(ISOBUTYL 2 CYANOACRYLATE);

ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG STABILITY; ENZYME ACTIVITY; INTESTINE MUCOSA; MUCUS; NONHUMAN; RAT;

EID: 0035073634     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Jejunal absorption, pharmacological activity and pharmacokinetic evaluation of indomethacin-loaded poly(d,I-lactide) and poly(isobutyl-cyanoacrylate) nanocapsules in rats
2. Polyalkylcyanoacrylate nanocapsules increase the intestinal absorption of a lipophilic drug
3. Disposition kinetics and oral bioavailability of vincamine-loaded polyalkyl cyanoacrylate nanoparticles
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6. Intestinal translocation of particulates
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11. Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: Preparation, morphological and sportive properties
12. Degradation of poly(isobutyl cyanoacrylate) nanoparticles
13. The use of bioadhesive in targeted delivery within the gastro-intestinal tract
14. The effect of gastro-intestinal mucus on drug absorption