Different mechanisms in inhibition of rat macrophage nitric oxide synthase expression by FK 506 and cyclosporin A

Immunopharmacology and Immunotoxicology

Volumn 23, Issue 1, 2001, Pages 67-74

  Strestikova P ^a   Strestíková, Petra ^a   Otova B ^b   Filipec, M ^a   Masek, K ^a   Farghali, H ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b Institute of Biology   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; RNA; TACROLIMUS;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG MECHANISM; GENE EXPRESSION; MALE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELLS, CULTURED; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ELECTROPHORESIS, AGAR GEL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNOSUPPRESSIVE AGENTS; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TACROLIMUS;

ANIMALIA;

EID: 0035073565     PISSN: 08923973     EISSN: None     Source Type: Journal    
DOI: 10.1081/IPH-100102568     Document Type: Article

References (17)

1. A tacrolimus-related immunosuppressant with reduced toxicity
2. Cyclosporin A and FF 506: Molecular mechanisms of immunosuppression and probes for transplantation biology
3. Differences in the mode of action of cyclosporine and FF 506
4. NOS2 mediates opposing effects in models of acute and chronic cardiac rejection
5. Apoptosis and increased expression of inducible nitric oxide synthase in human allograft rejection
6. Role of nitric oxide following cardiac transplantation
7. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
8. Inhibitory effect of FF 506 and cyclosporin A on nitric oxide production by LPS-treated cultured rat macrophages
9. Macrophage oxidation of L-arginin to nitrite and nitrate: Nitric oxide is an intermediate
10. A specific sequence of stimulation is required to induce synthesis of the antimicrobial molecule nitric oxide by mouse macrophages
11. Nitric oxide synthases in mammals
12. Nitric oxide. A novel signal transduction mechanism for transcellular communication
13. Nitric oxide IV. Determinants of nitric oxide protection and toxicity in liver
14. Inflammation, immunoregulation, and inducible nitric oxide synthase
15. Nitric oxide in autoimmune disease: Cytotoxic or regulatory mediator?
16. Nitric oxide as a secretory product of mammalian cells
17. Nitric oxide synthases: Roles, tolls, and controls