A comparative study of an in situ adapted diffusion cell and an in vitro Franz diffusion cell method for transdermal absorption of doxylamine

European Journal of Pharmaceutical Sciences

Volumn 13, Issue 2, 2001, Pages 169-177

  Venter, J P ^a   Muller, D G ^a   Du Plessis, J ^a   Goosen, C ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Absorption; Doxylamine; In situ; In vitro; Transdermal

Indexed keywords

ABSORPTION; DIFFUSION; OPTICAL MICROSCOPY; SKIN;

PERMEATION STUDIES;

DRUG THERAPY;

DOXYLAMINE; MEPYRAMINE MALEATE;

ARTICLE; DIFFUSION; DRUG ABSORPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NUDE MOUSE; PRIORITY JOURNAL; SKIN ABSORPTION; SKIN PENETRATION; STRATUM CORNEUM;

ADMINISTRATION, CUTANEOUS; ANALYSIS OF VARIANCE; ANIMALS; ANTI-ALLERGIC AGENTS; DOXYLAMINE; EPIDERMIS; MALE; MICE; MICE, NUDE; PERMEABILITY; SKIN ABSORPTION;

EID: 0035073302     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(01)00110-5     Document Type: Article

References (17)

1. Some problems in predicting human percutaneous absorption via in vitro animal models
2. Topical preparations
3. Methods for in vitro percutaneous absorption studies. IV. The flow-through diffusion cell
4. In vitro absorption/metabolism studies in human and animal skin
5. In vitro percutaneous penetration through hairless rat skin: influence of temperature, vehicle and penetration enhancers
6. Skin permeability
7. A modelistic approach showing the importance of the stagnant aqueous layers in in vitro diffusion studies and in vitro-in situ correlations
8. In vivo and in vitro penetration of topically applied compounds
9. Advances in topical corticosteroid therapy
10. Development and evaluation of an intracutaneous depot formulation of corticosteroids using Transcutol as a cosolvent: in vitro, ex vivo and in vivo rat studies
11. Health problems during pregnancy
12. Model membranes in predicting percutaneous absorption
13. Solute structure as a determinant of iontophoretic transport
14. Evaluation of silicone-based pressure-sensitive adhesives for transdermal drug delivery. II. Effect of penetrant lipophilicity