Depression of windup of spinal neurons in the neonatal rat spinal cord in vitro by an NK3 tachykinin receptor antagonist

Journal of Neurophysiology

Volumn 85, Issue 4, 2001, Pages 1502-1511

  Barbieri, Mario ^a,b   Nistri, Andrea ^a  

^a SISSA   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR ANTAGONIST; OSANETANT; SENKTIDE; SUBSTANCE P METHYL ESTER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL ROOT; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPIKE WAVE; SPINAL CORD NERVE CELL; SYNAPTIC TRANSMISSION;

EID: 0035072613     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.2001.85.4.1502     Document Type: Article

References (60)

1. Cyclic AMP regulates the expression of neurokinin 1 receptors by neonatal rat spinal neurons in culture
2. NT-3 evokes an LTP-like facilitation of AMPA/kainate receptor-mediated synaptic transmission in the neonatal rat spinal cord
3. NMDA receptor-independent mechanisms responsible for the rate of rise of cumulative depolarization evoked by trains of dorsal root stimuli on rat spinal motoneurones
4. Sensitization of pain pathways in the spinal cord: Cellular mechanisms
5. An NK1 receptor-dependent component of the slow excitation recorded intracellularly from rat motoneurons following dorsal root stimulation
6. Contribution of NMDA and non-NMDA glutamate receptors to locomotor pattern generation in the neonatal rat spinal cord
7. Potency and selectivity of the tachykinin NK3 receptor antagonist SR 142801
8. Ontogeny and characterization of [125I]Bolton Hunter-eledoisin binding sites in rat spinal cord by quantitative autoradiography
9. Modulation of excitatory amino acid responses by tachykinins and selective tachykinin receptor agonists in the rat spinal cord
10. Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat
11. Effects of competitive NMDA receptor antagonists on excitatory amino acid-evoked currents in mouse spinal cord neurones
12. SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor
13. Multiple types of tachykinin receptor mediate a slow excitation of rat spinal motoneurones in vitro
14. Substance P and TRH share a common effector pathway in rat spinal motoneurones: An in vitro electrophysiological investigation
15. Receptors mediating tachykinin-evoked depolarisations of neurons in the neonatal rat spinal cord
16. Electrophysiological properties of neonatal rat motoneurones studied in vitro
17. Effects of a tachykinin NK3 receptor antagonist, SR 142801, studied in isolated neonatal rat spinal cord
18. Tachykinin-induced activation of non-specific cation conductance via NK3 neurokinin receptors in guinea-pig intracardiac neurones
19. Wind-up of spinal cord neurones and pain sensation: Much ado about something?
20. Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states
21. Nonselective cation channels coupled with tachykinin receptors in rat sensory neurons
22. Excitatory and inhibitory transmission from dorsal root afferents to neonate rat motoneurons in vitro
23. Excitatory amino acid receptor-mediated neurotransmission from cutaneous afferents in rat dorsal horn in vitro
24. The effects of neurokinin-1 receptor agonists on spinal motoneurones of the neonatal rat
25. Peptides and the primary afferent nociceptor
26. Time-dependent changes in neurokinin(3) receptors and tachykinins during adjuvant-induced peripheral inflammation in the rat
27. NMDA-receptor regulation of substance P release from primary afferent nociceptors
28. Characteristics of substance P-evoked release of amino acids from neonatal rat spinal cord
29. Tachykinin receptors and tachykinin receptor antagonists
30. Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues
31. Responses of single dorsal cells to peripherial cutaneous unmyelinated fibers
32. Neurokinin-3 receptor distribution in rat and human brain: An immunohistochemical study
33. Age and species-dependent differences in the neurokinin B system in rat and human brain
34. Modulation of regenerative membrane properties by stimulation of metabotropic glutamate receptors in rat deep dorsal horn neurons
35. Ionic basis for plateau potentials in deep dorsal horn neurons of the rat spinal cord
36. Tachykinins modulate multiple ionic conductances in voltage-clamped rat spinal dorsal horn neurons
37. NK1 and NK2 receptors contribute to C-fibre evoked slow potentials in the spinal cord
38. Differential localization of tachykinin receptors in rat spinal cord
39. Electrophysiology of mammalian spinal cord in vitro
40. Neurotransmitter functions of mammalian tachykinins
41. Synaptic excitation of alpha-motoneurons by dorsal root afferents in the neonatal rat spinal cord
42. Intracellular responses of dorsal horn cells to cutaneous and sural nerve A and C fiber stimuli
43. Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord
44. Receptors and antagonists for substance P and related peptides
45. 2+ channels
46. Plateau-generating neurones in the dorsal horn in an in vitro preparation of the turtle spinal cord
47. Modulation of plateau properties in dorsal horn neurones in a slice preparation of the turtle spinal cord
48. Identification and characterization of rhythmic nociceptive and non-nociceptive spinal dorsal horn neurons in the rat
49. NK-3 receptors mediate enhancement of substance P release from capsaicin-sensitive spinal cord afferent terminals
50. Relationship of NK3 receptor-immunoreactivity to subpopulations of neurons in rat spinal cord
51. Rate of rise of the cumulative depolarization evoked by repetitive stimulation of small-caliber afferents is a predictor of action potential windup in rat spinal neurons in vitro
52. AMPA and NMDA receptor-dependent spinal LTP after nociceptive tetanic stimulation
53. Small-caliber afferent inputs produce a heterosynaptic facilitation of the synaptic responses evoked by primary afferent A-fibers in the neonatal rat spinal cord in vitro
54. Injury-induced plasticity of spinal reflex activity: NK1 neurokinin receptor activation and enhanced A- and C-fiber mediated responses in the rat spinal cord in vitro
55. Activity-dependent changes in rat ventral horn neurons in vitro; summation of prolonged afferent evoked postsynaptic depolarisations produce a D-2-amino-5-phosphovaleric acid sensitive windup
56. Is there a nociceptive carousel?
57. Modulation of spinal excitability: Co-operation between neurokinin and excitatory amino acid neurotransmitters
58. Evidence for a central component of post-injury pain hypersensitivity
59. Highly selective agonists for substance P receptor subtypes
60. Immunoelectron microscopic localization of NK-3 receptor in the rat spinal cord