P53-dependent apoptosis induced by proteasome inhibition in mammary epithelial cells

Cell Death and Differentiation

Volumn 8, Issue 3, 2001, Pages 210-218

  MacLaren, A P ^a   Chapman, R S ^a   Wyllie, A H ^b   Watson, C J ^b  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

26S proteasome; Apoptosis; KIM 2 mammary epithelial cells; P53

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BINDING PROTEIN; PROTEASOME; PROTEIN P53; VIRUS T ANTIGEN;

ALLELE; ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CELL CYCLE; CELL DEATH; CELL LINE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE; TEMPERATURE SENSITIVITY;

ANIMALS; ANNEXIN A5; ANTIGENS, VIRAL, TUMOR; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; LEUPEPTINS; MAMMARY GLANDS, ANIMAL; MICE; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MURINAE;

EID: 0035072563     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400801     Document Type: Article

References (25)

1. Proteasomes: Destruction as a programme
2. A 26S protease subunit that binds ubiquitin conjugates
3. Signal induced site specific phosphorylation target of IκBα to the ubiquitin-proteasome pathway
4. Cyclin is degraded by the ubiquitin pathway
5. Cell death: The significance of apoptosis
6. The C. elegans death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
7. A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland
8. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC Class I molecules
9. Proteasomes play an essential role in thymocyte apoptosis
10. Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons
11. Activation of the cell death program by inhibition of proteasome function
12. Viral T-antigen interactions with cellular protooncogenes and anti-oncogene products
13. Apoptosis and the cell cycle
14. The E6 oncoprotein encoded by human papillomaviruses types 16 and 18 promotes the degradation of p53
15. mdm2 and bax, Downstream mediators of the p53 Response, Are degraded by the Ubiquitin-Proteasome Pathway
16. p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function for EGF and insulin
17. p53-dependent and independent links between DNA damage, apoptosis and mutation frequency in ES cells
18. Ordering S-phase and M-phase in the cell cycle
19. p53-dependent induction of apoptosis by proteasome inhibitors
20. An inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces arrest in G2-phase and metaphase in HeLa cells
21. A chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme
22. Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant
23. p53 involvement in control of G2 exit of the cell cycle: Role in DNA damage-induced apoptosis
24. The retinoblastoma gene product protect E2F-1 from degradation by the ubiquitin proteasome pathway
25. Expression of transcription factor E2F1 induces quiescent cells to enter S-phase