Lack of pharmacokinetic interaction between moxifloxacin, a novel 8-methoxyfluoroquinolone, and theophylline

Clinical Pharmacokinetics

Volumn 40, Issue , 2001, Pages 63-70

  Stass, Heino ^a   Kubitza, Dagmar ^a  

^a BAYER AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; MOXIFLOXACIN; THEOPHYLLINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; DRUG URINE LEVEL; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANALYSIS OF VARIANCE; ANTI-INFECTIVE AGENTS; AREA UNDER CURVE; AZA COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP1A1; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; FLUOROQUINOLONES; HALF-LIFE; HUMANS; LINEAR MODELS; LIVER; MALE; PHOSPHODIESTERASE INHIBITORS; QUINOLINES; THEOPHYLLINE;

EID: 0035072085     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-200140001-00009     Document Type: Article

References (5)

1. Dalhoff A, Petersen U, Endermann R. In vitro activity of BAY 12-8039, a new 8-methoxyquinolone. Chemotherapy 1996; 42: 410-25
2. Troger U, Meyer FP Influence of endogenous and exogenous effectors on the pharmacokinetics of theophylline. Focus on biotransformation. Clin Pharmacokinet 1995; 28: 287-314
3. Matuschka PR, Vissing RS. Clinafloxacin-theophylline drug interaction. Ann Pharmacother 1995; 29: 378-80
4. Schaefer HG, Ahr G, Kuhlmann J. Pharmacokinetic development of quinolone antibiotics. Int J Clin Pharmacol Ther 1995; 33: 266-76
5. Mizuki Y, Fujiwara I, Yamaguchi T. Pharmacokinetic interactions related to the chemical structures of fluoroquinolones. J Antimicrob Chemother 1996; 37 Suppl. A: 41-5