Synergistic effects of verapamil and anti-mdr1 ribozyme on reversion of multidrug resistance in the P-glycoprotein-positive K562 cell line [2]

Leukemia

Volumn 15, Issue 4, 2001, Pages 696-697

  Gong, Y ^a,b   Han, W ^b   Liu, J ^b   Chen, F ^c   Han, J ^c   Jin, Y ^b   Ou Yong, R ^c  

^a FIRST AFFILIATED HOSPITAL   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DAUNORUBICIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; RIBOZYME; VERAPAMIL;

CARDIOTOXICITY; CELL STRAIN K 562; CONTROLLED STUDY; DOT HYBRIDIZATION; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIVITY; DRUG TRANSPORT; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LETTER; LEUKEMIA; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

EID: 0035071992     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402072     Document Type: Letter

References (5)

1. P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil
2. Reversion of multidrug resistance in the P-glycoprotein-positive human pancreatic cell line (EPP85-181RDB) by introduction of a hammerhead ribozyme
3. Tumor-specific expression of anti-mdr1 ribozyme selectively restores chemosensitivity in multidrug-resistant colon-adenocarcinoma cells
4. Restoration of retinoid sensitivity by MDR1 ribozymes in retinoic acid-resistant myeloid leukemic cells
5. Comparison of three commercially available antibodies for flow cytometric monitoring of P-glycoprotein expression in tumor cells