Effects of ozone exposure on nuclear factor-κB activation and tumor necrosis factro-α expression in human nasal epithelial cells

Toxicological Sciences

Volumn 60, Issue 2, 2001, Pages 356-362

  Nichols, B G ^a   Woods, J S ^a   Luchtel, D L ^a   Corral, J ^a   Koenig, J Q ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Airway; Cell culture; Cytokine; Electron spin resonance; Epithelial cell; Free radical; Inflammation; Nasal cell; Ozone; Transcription factor; Tumor necrosis factor

Indexed keywords

COLLAGEN; FREE RADICAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR PROTEIN; OZONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; AIR; ARTICLE; CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ELECTROPHORETIC MOBILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; EXPOSURE; FEMALE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; MALE; NOSE MUCOSA; TISSUE CULTURE;

ADULT; AGED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; FEMALE; FREE RADICALS; HUMANS; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; NASAL MUCOSA; NF-KAPPA B; OZONE; TUMOR NECROSIS FACTOR-ALPHA; TURBINATES;

EID: 0035071236     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/60.2.356     Document Type: Article

References (29)

1. Ozone-induced airway inflammation in human subjects as determined by airway lavage and biopsy
2. Effects of ozone on normal and potentially sensitive human subjects: I. Airway inflammation and responsiveness to ozone in normal and asthmatic subjects
3. NF-κB: A pivotal role in asthma and a new target for therapy
4. Transcription factors and asthma
5. Function and activation of NF-κB in the immune system
6. Ozone can increase the expression of intercellular adhesion molecule-1 and the synthesis of cytokines by human nasal epithelial cells
7. Consideration in the spin trapping of superoxide and hydroxyl radical in aqueous systems using 5,5-dimethyl-1-pyrroline-1-oxide
8. A role for transcription factor NF-κB in inflammation
9. Induction of nuclear factor-κB by exposure to ozone and inhibition by glucocorticoids
10. Quantifying aldehydes and distinguishing aldehydic product profiles from autoxidation and ozonation of unsaturated fatty acids
11. The effects of ozone exposure on lactate dehydrogenase release from human and primate-respiratory epithelial cells
12. Reaction products of ozone: A review
13. Ozone induction of cytokine-induced neutrophil chemoattractant (CINC) and nuclear factor-κB in rat lung: Inhibition by corticosteroids
14. Activation of the transcription factor NF-κB in human tracheobronchial epithelial cells by inflammatory stimuli
15. Ozone-induced IL-8 expression and transcription factor binding in respiratory epithelial cells
16. Effect of ozone on respiratory responses in subjects with asthma
17. The role of reactive oxygen and nitrogen species in airway epithelial gene expression
18. Human nasal epithelium: Characterization and effects of in vitro exposure to sulfur dioxide
19. Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of γ-glutamylcysteine synthetase
20. Mechanisms of radical formation from reactions of ozone with target molecules in the lung
21. Radical production from the interaction of ozone and PUFA as demonstrated by electron spin resonance spin-trapping techniques
22. Regulation of nuclear factor-κB, activator protein-1, and glutathione levels by tumor necrosis factor-α and dexamethasone in aveolar epithelial cells
23. Molecular mechanisms of the regulation of glutathione synthesis by tumor necrosis factor-α and dexamethasone in human alveolar epithelial cells
24. Ozone-induced mediator release from human bronchial epithelial cells in vitro and the influence of nedocromil sodium
25. Proliferation of airway epithelium after ozone exposure: Effect of apocynin and dexamethasone
26. Reactive oxygen intermediates activate NF-κB in a tyrosine kinase dependent mechanism, and in combination with vanadate, activate the p561 and p59fyn tyrosine kinases in human lymphocytes
27. Nuclear factor κB: A oxidative stress-responsive transcription factor of eukaryotic cells (a 1 view)
28. Activation of NF-κB in normal rat kidney epithelial (NRK52E) cells mediated via a redox-insensitive, calcium-dependent pathway
29. Cellular, biochemica and functional effects of ozone: New research and perspective on ozone health effects