Pharmacokinetic aspects of chloroquine-induced pruritus: Influence of dose and evidence for varied extent of metabolism of the drug

European Journal of Pharmaceutical Sciences

Volumn 13, Issue 2, 2001, Pages 195-201

  Onyeji, C O ^a   Ogunbona, F A ^a  

^a OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

Author keywords

Chloroquine disposition; Dose influence; Induced pruritus

Indexed keywords

DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM;

PRURITUS POSITIVE VOLUNTEERS;

PHARMACOKINETICS;

CHLOROQUINE; DEETHYLCHLOROQUINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG METABOLISM; DRUG URINE LEVEL; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; PRURITUS; VOLUNTEER;

ADULT; ANTIMALARIALS; AREA UNDER CURVE; CHLOROQUINE; HUMANS; MALE; PRURITUS;

EID: 0035071035     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(01)00108-7     Document Type: Article

References (26)

1. Effects of two antihistamines on chloroquine and histamine-induced weal and flare in health African volunteers
2. Chloroquine-induced pruritus in malaria parasitaemia and the effects of prednisolone, niacin, and their combinations compared with antihistamines
3. Prevalence of chloroquine-induced pruritus: evidence for heredofamilial factors
4. The disposition of chloroquine and its main metabolite desethylchloroquine in volunteers with and without pruritus: evidence for decreased metabolism of chloroquine in volunteers with pruritus
5. Selective pharmacokinetic properties of chloroquine and desethylchloroquine in humans
6. Effect of chloroquine on histamine-induced bronchial asthma in guinea pig
7. Interindividual variations in drug disposition: clinical implications and methods of investigation
8. Defective oxidation of drugs. Pharmacokinetics and therapeutic implications
9. Sensitivity of Plasmodium falciparum to chloroquine and sulfadoxine/pyrimethamine in Nigerian Children
10. Chloroquine disposition in hypersensitive and nonhypersensitive subjects and the significance in chloroquine-induced pruritus
11. Urine methylhistamine concentrations before and after chloroquine in healthy black subjects
12. Polymorphic drug oxidation: pharmacokinetics basis and comparison of experimental indices
13. The melanin affinity of chloroquine and chlorpromazine studied by whole autoradiography
14. Chloroquine-induced pruritus: its impact on chloroquine utilization in malaria control in Dares Salaam
15. Liquid chromatographic analysis of chloroquine and desethylchloroquine in human plasma, saliva and urine
16. Onset of pruritogenicity of chloroquine and its implication for suppressive therapy
17. Chloroquine-induced pruritus and sickle cell trait in Africans: possible pharmacogenetic relationship
18. Chloroquine concentrations in the skin of rabbits and man
19. The practical and therapeutic implications of chloroquine-induced itching in tropical Africa
20. Mechanism of chloroquine-induced body-scratching behavior in rats: evidence of involvement of endogenous opioid receptors
21. Lack of pharmacokinetic interaction between chloroquine and imipramine
22. Mechanism of enhanced pruritogenicity of chloroquine among patients with malaria: a review
23. The antipruritic effects of chlorpheniramine, cyproheptadine, and sulphapryridine monitored with limb activity meters on chloroquine-induced pruritus among patients with malaria
24. Chloroquine-associated pruritus in a European
25. Enhanced efficacy of chloroquine-chlorpheniramine combination in acute uncomplicated falciparum malaria in children
26. Genetic and environmental factors affecting drug disposition in man