Autoantibodies to filaggrin/deiminated fibrin (AFA) are useful for the diagnosis and prognosis of rheumatoid arthritis, and are probably involved in the pathophysiology of the disease

Joint Bone Spine

Volumn 68, Issue 2, 2001, Pages 103-105

  Serre, Guy ^a  

^a INSERM   (France)

Author keywords

Antifilaggrin antibodies; Antikeratin antibodies; Rheumatoid arthritis

Indexed keywords

AUTOANTIBODY; FIBRIN ANTIBODY; FILAGGRIN ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; ANTIBODY PRODUCTION; DIAGNOSTIC VALUE; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE SEVERITY; EDITORIAL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOBLOTTING; PATHOPHYSIOLOGY; RHEUMATOID ARTHRITIS; SENSITIVITY AND SPECIFICITY;

EID: 0035070717     PISSN: 1297319X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1297-319X(01)00259-7     Document Type: Editorial

References (21)

1. A new serum factor in patients with rheumatoid arthritis, the antiperinuclear factor
2. Antikeratin antibodies in rheumatoid arthritis
3. Anti-perinuclear factor versus the so-called "antikeratin antibodies" and antibodies to human epidermis filaggrin, in the diagnosis of arthritides
4. High diagnostic value in rheumatoid arthritis of antibodies to the stratum corneum of rat oesophagus epithelium, so-called "antikeratin antibodies"
5. The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis
6. Characterisation of the rat oesophagus epithelium antigens defined by the so-called "antikeratin antibodies," specific for rheumatoid arthritis
7. The antiperinuclear factor and the so-called "antikeratin antibodies" are the same rheumatoid arthritis-specific autoantibodies
8. The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are post-translationally generated on various sites of (pro)filaggrin by deimination of arginine residues
9. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies
10. The Sa system: A novel antigen-antibody system specific for rheumatoid arthritis
11. Insights into rheumatoid arthritis derived from the Sa immune system
12. Immunoblotting detection of so-called "antikeratin antibodies": A new assay for the diagnosis of rheumatoid arthritis
13. Immunoblotting detection of autoantibodies to human epidermis filaggrin: A new diagnostic test for rheumatoid arthritis
14. Purification of filaggrin from human epidermis and measurement of antifilaggrin autoantibodies in sera from patients with rheumatoid arthritis by an enzyme-linked immunosorbent assay
15. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide
16. In the rheumatoid pannus, antifilaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum
17. The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the α and ß chains of fibrin
18. From systemic T cell self-reactivity to organspecific autoimmune disease via immunoglobulins
19. A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?