Quantitative exposure assessment: Application of physiologically-based pharmacokinetic (PBPK) modeling of low-dose, long-term exposures of organic acid toxicant in the brain

Environmental Toxicology and Pharmacology

Volumn 9, Issue 4, 2001, Pages 153-160

  Kim, Chung S ^a   Sandberg, Jennifer A ^b   Slikker Jr , William ^b   Binienda, Zbigniew ^b   Schlosser, Paul M ^c   Patterson, Tucker A ^b  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^c CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

Brain; Long term exposures; Low dose; Physiologically based pharmacokinetic (PBPK) modeling

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; CARBOXYLIC ACID;

ARTERIAL BLOOD; ARTICLE; BLOOD BRAIN BARRIER; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG CLEARANCE; ENVIRONMENTAL EXPOSURE; FOOD CONTAMINATION; LONG TERM EXPOSURE; MODEL; NEUROTOXICITY; NONHUMAN; PHYSIOLOGY; PREDICTION; PRIORITY JOURNAL; RAT; TARGET ORGAN; VALIDATION PROCESS; VENOUS BLOOD;

ORYCTOLAGUS CUNICULUS;

EID: 0035069521     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(01)00060-6     Document Type: Article

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