Structural diversity despite strong evolutionary conservation in the 5′-untranslated region of the P-type dystrophin transcript

Molecular and Cellular Neuroscience

Volumn 17, Issue 3, 2001, Pages 500-513

  Abdulrazzak, Hassan ^a   Noro, Nobuhiro ^b   Simons, J Paul ^a   Goldspink, Geoffrey ^a   Barnard, Eric A ^c   Górecki, Dariusz C ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DYSTROPHIN; MESSENGER RNA;

5' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; ARTICLE; BIODIVERSITY; CEREBELLUM; CODON; CONTROLLED STUDY; DNA FLANKING REGION; GENETIC CONSERVATION; HUMAN; INTRON; MOUSE; MUSCLE; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; TRANSCRIPTION INITIATION;

EPICOCCUM; GALLUS GALLUS; MAMMALIA;

EID: 0035069033     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.2000.0950     Document Type: Article

References (54)

1. Tissue specific expression of an alpha-skeletal actin-lacZ fusion gene during development in transgenic mice
2. Regulation of gene expression by alternative promoters
3. Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences
4. Structural diversity in the 5′-untranslated region of cytokine-stimulated human inducible nitric oxide synthase mRNA
5. Evolutionary origins and maintenance of redundant gene expression during metazoan development
6. X-linked dilated cardiomyopathy and the dystrophin gene
7. Evolution of the dystrophin muscular promoter and 5′ flanking region in primates
8. Expression of the dystrophin complex in the brain
9. Specific expression of G-dystrophin (Dp71) in the brain
10. Expression of the dystrophin gene in mouse and rat brain
11. Expression of four alternative dystrophin transcripts in brain regions regulated by different promoters
12. Kainate-evoked changes in dystrophin messenger RNA levels in the rat hippocampus
13. Control of translation initiation in animals
14. Dystrophin: The protein product of the Duchenne muscular dystrophy locus
15. Cell and fiber-type distribution of dystrophin
16. Expression and regulation of the dystrophin Purkinje promoter in human skeletal muscle, heart, and brain
17. Tissue-selective expression of alphadystrobrevin is determined by multiple promoters
18. Mechanisms for selecting 5′ splice sites in mammalian pre-mRNA splicing
19. Localization of dystrophin gene transcripts during mouse embryogenesis
20. Striking conservation of the brain-specific region of the dystrophin gene
21. Translational controls impinging on the 5′-untranslated region and initiation factor proteins
22. 2.1 kb 5′-flanking region of the brain type dystrophin gene directs the expression of lacZ in the cerebral cortex, but not in the hippocampus
23. A 900 bp genomic region from the mouse dystrophin promoter directs lacZ reporter expression only to the right heart of transgenic mice
24. Molecular and functional analysis of the muscle-specific promoter region of the Duchenne muscular dystrophy gene
25. A receptors in mice lacking dystrophin
26. Initiation of translation in prokaryotes and eukaryotes
27. The chicken dystrophin cDNA: Striking conservation of the C-terminal coding and 3′ untranslated regions between man and chicken
28. Dystrophin in the nervous system
29. Brain-type and muscle-type promoters of the dystrophin gene differ greatly in structure
30. An autoradiographic analysis of histogenesis in the mouse cerebellum
31. A mutation in the dystrophin gene selectively affecting dystrophin expression in the heart
32. Transcription of the dystrophin gene in normal tissues and in skeletal muscle of a family with X-linked dilated cardiomyopathy
33. Deletions in the 5′ region of dystrophin and resulting phenotypes
34. Up-regulation of the brain and Purkinje-cell forms of dystrophin transcripts, in Becker muscular dystrophy
35. Multiple promoters direct stimulus and temporal specific expression of brain-derived neurotrophic factor in the somatosensory cortex
36. Construction, arraying, and high-density screening of large insert libraries of human chromosomes X and 21: Their potential use as reference libraries
37. MatInd and MatInspector - New fast and versatile tools for detection of consensus matches in nucleotide sequence data
38. Dystrophin and its isoforms
39. Regulation of a Purkinje cell-specific promoter by homeodomain proteins: Repression by engrailed-2 vs. synergistic activation by Hoxa5 and Hoxb7
40. A polymerase chain reaction screening strategy for the promoter of the canine dystrophin gene
41. A simple phase-extraction assay for CAT activity
42. Sequence of two rat insulin-like growth factor I mRNAs differing within the 5′ untranslated region
43. Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes
44. Six novel transcripts that remove a huge intron ranging from 250 to 800 kb are produced by alternative splicing of the 5′ region of the dystrophin gene in human skeletal muscle
45. Expression, regulation and localisation of dystrophin isoforms in human foetal skeletal and cardiac muscle
46. Facilitated NMDA receptor-mediated synaptic plasticity in the hippocampal CA1 area of dystrophin-deficient mice
47. The anatomy of the cerebellum
48. Neuronal NOS: Gene structure, mRNA diversity, and functional relevance
49. Frameshift deletions of exons 3-7 and revertant fibers in Duchenne muscular dystrophy: Mechanisms of dystrophin production
50. Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle
51. Alternative leader sequences in insulin-like growth factor I mRNAs modulate translational efficiency and encode multiple signal peptides
52. Disassembly of the cholinergic postsynaptic apparatus induced by axotomy in mouse sympathetic neurons: The loss of dystrophin and beta-dystroglycan immunoreactivity precedes that of the acetylcholine receptor