Inhibitory effects of nicorandil on rat mesangial cell proliferation via the protein kinase G pathway

Nephron

Volumn 87, Issue 3, 2001, Pages 263-268

  Segawa, Kayoko ^a   Minami, Kouichiro ^a   Shiga, Yousuke ^a   Shiraishi, Munehiro ^a   Sata, Takeyoshi ^a   Nakashima, Yasuhide ^a   Shigematsu, Akio ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

ATP sensitive potassium channel; Cell proliferation; cGMP; Mesangial cell; Nicorandil

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENYLATE CYCLASE ACTIVATOR; CROMAKALIM; CYCLIC GMP DEPENDENT PROTEIN KINASE; GLIBENCLAMIDE; GUANYLATE CYCLASE INHIBITOR; KT 5823; METHYLENE BLUE; NICORANDIL; NITRATE; POTASSIUM CHANNEL STIMULATING AGENT; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EFFECT; ENZYME ACTIVATION; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ALKALOIDS; ANIMALS; CARBAZOLES; CELL DIVISION; CELLS, CULTURED; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLOMERULAR MESANGIUM; GUANYLATE CYCLASE; INDOLES; MALE; METHYLENE BLUE; NICORANDIL; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; THYMIDINE;

EID: 0035068591     PISSN: 00282766     EISSN: None     Source Type: Journal    
DOI: 10.1159/000045924     Document Type: Article

References (25)

1. Mesangium and glomerular disease
2. The contribution of glomerular mesangial cells to progressive glomerulosclerosis
3. Effects of nicorandil on exercise tolerance in patients with stable effort angina: A double-blind study
4. Hemodynamic action of nicorandil in chronic congestive heart failure
5. Acute effects of increasing doses of nicorandil on renal function in man
6. Relationship between relaxatmion and cyclic GMP formation caused by nicorandil in canine mesenteric artery
7. Cyclic GMP as possible mediator of coronary arterial relaxation by nicorandil (SG-75)
8. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells
9. Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators
10. Mechanism of atrial natriuretic factor-induced inhibition of rat mesangial cell mitogenesis
11. Nipradilol inhibits DNA synthesis by regulating nitric oxide synthesis in cultured rat mesangial cells
12. Involvement of a Gardos-type potassium channel in head activator-induced mitosis of BON cells
13. Mitogenic signal transduction in human breast cancer cells
14. Glomerular mesangial cells: Electrophysiology and regulation of contraction
15. Inhibitory effect of adrenomedullin on rat mesangial cell mitogenesis
16. C-type natriuretic peptide inhibits rat mesangial cell proliferation by a phosphorylation-dependent mechanism
17. Inhibitory effect of the intravenous anesthetic, ketamine, on rat mesangial cell proliferation
18. Cyclic GMP and mechanisms of vasodilation
19. Cyclic-GMP-regulated enzymes and their possible physiological functions
20. +channels
21. Effects of nicorandil on cell proliferation and cholesterol ester accumulation in arterial smooth muscle cells in culture
22. cGMP-dependent protein kinase is present in high concentrations in contractile cells of the kidney vasculature
23. A novel biological effect of atrial natriuretic hormone: Inhibition of mesangial cell mitogenesis
24. Interaction of PDGF and natriuretic peptides on mesangial cell proliferation and endothelin secretion
25. Inhibition of ATP-sensitive potassium channels causes reversible cell-cycle arrest of human breast cancer cells in tissue culture