Basic experimental studies and clinical aspects of gadolinium salts and chelates

Cardiovascular Drug Reviews

Volumn 19, Issue 1, 2001, Pages 41-56

  Christofer Adding, L ^a   Bannenberg, Gerard L ^a   Gustafsson, Lars E ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Gadolinium chloride; Macrophage; Nuclear magnetic resonance imaging; Stretch; Stretch activated ion channels

Indexed keywords

GADOLINIUM CHELATE; GADOLINIUM CHLORIDE; GADOLINIUM PENTETATE;

CARDIOTOXICITY; CAT; DOSE RESPONSE; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG INHIBITION; DRUG MECHANISM; DRUG METABOLISM; GENE EXPRESSION; GUINEA PIG; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HUMAN; HYPOXEMIA; IMAGE ANALYSIS; KIDNEY FAILURE; MONONUCLEAR PHAGOCYTE; NONHUMAN; PRESSORECEPTOR; PRIORITY JOURNAL; RABBIT; REVIEW; VASCULAR ENDOTHELIUM;

EID: 0035066984     PISSN: 08975957     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3466.2001.tb00182.x     Document Type: Review

References (130)

1. Gadolinium chloride inhibition of pulmonary nitric oxide production and effects on pulmonary circulation in the rabbit
2. The calcium-sensing receptor stimulates JNK in MDCK cells
3. 2+ channel antagonists and, in contrast to freshly isolated hepatocytes, does not require a pertussis toxin-sensitive trimeric GTP-binding protein
4. 3+
5. Pulmonary macrophage function in systemic gadolinium chloride-pretreated rats
6. Stretch-induced stimulation of lower airway nitric oxide formation in the guinea-pig: Inhibition by gadolinium chloride
7. 3 and Gd-DTPA and their influence on proton magnetic relaxation in rats tissues
8. Gadolinium blocks low- and high-threshold calcium currents in pituitary cells
9. Stretching increases calcium influx and efflux in cultured pulmonary arterial smooth muscle cells
10. Gadolinium decreases stretch-induced vulnerability to atrial fibrillation
11. Gadolinium block of calcium channels: Influence of bicarbonate
12. The gadolinium ion: A potent blocker of calcium channels and catecholamine release from cultured chromaffin cells
13. Gadolinium chloride pretreatment protects against hepatic injury but predisposes the lungs to alveolitis after lipopolysaccharide administration
14. The acute mammalian toxicity of rare earth nitrates and oxides
15. 2+ (polyvalent cation)sensing receptor in rat pancreas
16. Plasmalogen-derived lysolipid induces a depolarizing cation current in rabbit ventricular myocytes
17. Using gadolinium to identify stretch-activated channels: Technical considerations
18. Extracellular calcium-sensing receptor is expressed in rat hepatocytes: Coupling to intracellular calcium mobilization and stimulation of bile flow
19. Structural versus functional modulation of the arterial baroreflex
20. Mechanisms of baroreceptor activation
21. Gadolinium induces domain and pore formation of human erythrocyte membrane: An atomic force microscopic study
22. Mechanosensitive currents in putative aortic baroreceptor neurons in vitro
23. Mechanical stimulation of neurites generates an inward current in putative aortic baroreceptor neurons in vitro
24. Lanthanide ion probes of calcium-binding sites on cellular membranes
25. Arrhythmia in heart failure: Role of mechanically induced changes in electrophysiology
26. Comparative pharmacokinetics of gadolinium DTPA and gadolinium chloride
27. Gadolinium selectively blocks a component of calcium current in rodent neuroblastoma x glioma hybrid (NG 108-15) cells
28. The involvement of Kupffer cells in carbon tetrachloride toxicity
29. Effects of gadolinium on ion channels in the myelinated axon of Xenopus laevis: Four sites of action
30. Lipid and cell membranes in the presence of gadolinium and other ions with high affinity to lipids. 2. A dipole component of the boundary potential on membranes with different surface charge
31. Contribution of macrophages to pulmonary nitric oxide production in septic shock
32. Acute renal failure after arteriography with a gadolinium-based contrast agent
33. Stretch-induced protection shares a common mechanism with ischemic preconditioning in rabbit heart
34. Gadolinium inhibits mechanoelectrical transduction in rabbit carotid baroreceptors. Implication of stretch-activated channels
35. Toxicological and pharmacological effects of gadolinium and samarium chlorides
36. The pharmacology of mechanogated membrane ion channels
37. Dose-dependent inhibition of stretch-induced arrhythmias by gadolinium in isolated canine ventricles. Evidence for a unique mode of antiarrhythmic action
38. Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation
39. Preclinical safety assessment and pharmacokinetics of gadodiamide injection, a new magnetic resonance imaging contrast agent
40. Kupffer cell production of cytokine-induced neutrophil chemo-attractant following ischemia/reperfusion injury in rats
41. Subcellular localization of gadolinium injected as soluble salt in rats: A microanalytical study
42. Gadolinium blocks the delayed rectifier potassium current in isolated guinea-pig ventricular myocytes
43. Mechanosensitive cation channels in aortic endothelium of normotensive and hypertensive rats
44. Mechanically activated currents in chick heart cells
45. Rare earth pneumoconiosis
46. Electron microscopic study of Kupffer-cell phagocytosis blockade induced by gadolinium chloride
47. 2+ influx and mating
48. Blockade of liver macrophages by gadolinium chloride reduces lethality in endotoxemic rats - Analysis of mechanisms of lethality in endotoxemia
49. Hypoosmotic shocks induce elevation of resting calcium level in Duchenne muscular dystrophy myotubes contracting in vitro
50. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver
51. Molecular identification of a eukaryotic, stretch-activated non-selective cation channel
52. Up-regulation of COX2 expression by uni-axial cyclic stretch in human lung fibroblast cells
53. A stretch-activated cation channel in the apical membrane of A6 cells
54. Gadolinium chloride inhibition of rat hepatic microsomal epoxide hydrolase and glutathlone S-transferase gene expression
55. Increased mechanosensitive currents in aortic endothelial cells from genetically hypertensive rats
56. Stretch-activated cation channel in human umbilical vein endothelium in normal pregnancy and in preeclampsia
57. Liver cysteine proteinases in macrophage depression induced by gadolinium chloride
58. Regulation of liver cysteine proteinases during macrophagal stimulation and depression
59. Selective depletion of Kupffer cells after intravenous injection of gadoliniumchloride
60. Mechanosensitive ion channels in putative aortic baroreceptor neurons
61. Different cytotoxic response to gadolinium between mouse and rat alveolar macrophages
62. Effects of gadolinium on length-dependent force in guinea-pig papillary muscle
63. The stretch-activated ion channel blocker gadolinium also blocks L-type calcium channels in isolated ventricular myocytes of the guinea-pig
64. Block of stretch-activated atrial natriuretic peptide secretion by gadolinium in isolated rat atrium
65. Role of calcium in stretch-induced release and mRNA synthesis of natriuretic peptides in isolated rat atrium
66. Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers?
67. Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen
68. The reticuloendothelial-blocking effect of rare earth metals in rats
69. Gadolinium chloride-induced shifts in intrahepatic distributions of liposomes
70. Molecular and functional properties of two-pore-domain potassium channels
71. Inhibition of mechanical strain-induced fetal rat lung cell proliferation by gadolinium, a stretch-activated channel blocker
72. Chemical toxicity of some actinides and lanthanides towards alveolar macrophages: An in vitro study
73. + channel
74. Changes in Kupffer cell phenotype and acinar location induced by intravenous gadolinium chloride
75. Gadolinium ion is the inhibitor suitable for testing the putative role of stretch-activated ion channels in geotropism and thigmotropism
76. Gadolinium induces macrophage apoptosis
77. 2+ mobilization to mechanical stretch in endothelial cells
78. Pp125FAK is required for stretch dependent morphological response of endothelial cells
79. Involvement of SA channels in orienting response of cultured endothelial cells to cyclic stretch
80. Role of Kupffer cells in interleukin-6 release following trauma-hemorrhage and resuscitation
81. Stretch preconditions canine myocardium
82. Gadolinium prevents high airway pressure-induced permeability increases in isolated rat lungs
83. Inhibition of macrophages with gadolinium chloride abrogates ozone-induced pulmonary injury and inflammatory mediator production
84. - channels by ACh and ATP in Xenopus follicles
85. Inhibition of anaphylatoxin C3a- and C5a- but not nerve stimulation- or noradrenaline-dependent increase in glucose output and reduction of flow in Kupffer cell-depleted perfused rat livers
86. Gadolinium chloride alters the acinar distribution of phagocytosis and balance between pro- and anti-inflammatory cytokines
87. Medicinal applications of heavy-metal compounds
88. Time course of stomach mineralization, plasma, and urinary changes after a single intravenous administration of gadolinium (111) chloride in the male rat
89. Kupffer cell depletion partially prevents hepatic heme oxygenase 1 messenger RNA accumulation in systemic inflammation in mice: Role of interleukin Ibeta
90. Murine Kupffer cells and hepatic natural killer cells regulate tumor growth in a quantitative model of colorectal liver metastases
91. Lymphocyte suppression by Kupffer cells prevents portal venous tolerance induction: A study of macrophage function after intravenous gadolinium
92. Gadolinium chloride inhibits Kupffer cell nitric oxide synthase (iNOS) induction
93. 2- concentration through mobilization of intracellular and extracellular pools
94. Contrast media research
95. In vivo assessment of hepatic alterations following gadolinium chloride-induced Kupffer cell blockade
96. Long-term occupational risk of rare-earth pneumoconiosis. A case report as investigated by neutron activation analysis
97. Fluid shear stress increases transforming growth factor beta 1 expression in human osteoblast-like cells: Modulation by cation channel blockades
98. 2-, used as a contrast agent in magnetic resonance imaging
99. Stretch-activated whole-cell currents in smooth muscle cells from mesenteric resistance artery of guinea-pig
100. Gadolinium chloride removes pulmonary intravascular macrophages and curtails the degree of ovine lentivirus-induced lymphoid interstitial pneumonia
101. Gadolinium chloride toxicity in the mouse
102. Gadolinium chloride toxicity in the rat
103. Gadolinium-based contrast agents in angiography and interventional radiology
104. Stretch-induced depolarizations as a trigger of arrhythmias in isolated canine left ventricles
105. Flow stimulates nitric oxide release in guinea pig heart: Role of stretch-activated ion channels
106. Low calcium environment effects osteoprotegerin Ligand/Osteoclast differentiation factor
107. Time course study of the influence of acute iron overload on Kupffer cell functioning and hepatotoxicity assessed in the isolated perfused rat liver
108. Mechanical stretch increases intracellular calcium concentration in cultured ventricular cells from neonatal rats
109. Effect of gadolinium on stretch-induced changes in contraction and intracellularly recorded action- and afterpotentials of rat isolated atrium
110. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin
111. Calcium channels and intestinal fluid secretion: An experimental study in vivo in rats
112. Mechanosensitive calcium entry and mobilization in renal A6 cells
113. Elimination, blocking, and activation of macrophages: Three of a kind?
114. 4
115. Rare earth deposits in a deceased movie projectionist. A new case of rare earth pneumoconiosis?
116. Utilization of electron probe microanalysis in gadolinium-treated mice
117. Characterstics of Gd-DTPA and new derivatives
118. Characteristics of gadolinium-DTPA complex: A potential NMR contrast agent
119. Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers
120. Stretch-activated nonselective cation channels in urinary bladder myocytes: Importance for pacemaker potentials and myogenic response
121. Intramyocardial injections and protection against myocardial ischemia. An attempt to examine the cardioprotective actions of adenosine
122. Effects of intermittent pressure-induced strain on the electrophysiology of cultured human chondrocytes: Evidence for the presence of stretch-activated membrane ion channels
123. Cyclical strain increases monocyte chemotactic protein-1 secretion in human endothelial cells
124. Mechanical strain induces constitutive and regulated secretion of glycosaminoglycans and proteoglycans in fetal lung cells
125. Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions
126. Effects of gadolinium chloride on the rat lung following intratracheal instillation
127. Lack of nitric oxide sensitivity of carotid sinus baroreceptors activated by normal blood pressure stimuli in cats
128. 2+ exchanger current in guinea-pig isolated ventricular myocytes