Arg615cys substitution in pig skeletal ryanodine receptors increases activation of single channels by a segment of the skeletal DHPR II-III loop

Biophysical Journal

Volumn 80, Issue 4, 2001, Pages 1769-1782

  Gallant, Esther M ^a   Curtis, Suzanne ^a   Pace, Suzy M ^a   Dulhunty, Angela F ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDROPYRIDINE RECEPTOR; ARGININE; CALCIUM CHANNEL; CYSTEINE; PEPTIDE DERIVATIVE; RYANODINE RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; MEMBRANE CURRENT; NONHUMAN; RECEPTOR UPREGULATION; SARCOPLASMIC RETICULUM; SKELETAL MUSCLE; SWINE;

SUS SCROFA;

EID: 0035066427     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(01)76147-4     Document Type: Article

References (3)

1. Bhat, M. B., J. Zhao, H. Takeshima, and J. Ma. 1997. Functional calcium release channel formed by the carboxyl-terminal portion of ryanodine receptor. Biophys. J. 73:1329-1336.
2. Casarotto, M. G., F. Gibson, S. M. Pace, S. M. Curtis, M. Mulcair, and A. F. Dulhunty. 2000. A structural requirement for activation of skeletal RyRs by a 20 amino acid region of the II-III loop of the skeletal DHPR. J. Biol. Chem. 275:11631-11637.
3. Chaudhari, N. 1992. A single nucleotide deletion in the skeletal muscle specific transcript of muscular dysgenisis (mdg) mice. J. Biol. Chem. 267:25636-25639.