Androgen metabolism in regenerating liver of male rats: Evidence for active uptake and utilization of testosterone

Hepatology Research

Volumn 20, Issue 1, 2001, Pages 114-127

  Yamaguchi, Minekazu ^a   Yu, Liqun ^a   Nazmy El Assal, Osama ^a   Satoh, Takashi ^a   Kumar Dhar, Dipok ^a   Yamanoi, Akira ^a   Nagasue, Naofumi ^a  

^a SHIMANE UNIVERSITY   (Japan)

Author keywords

Androgen metabolism; Liver regeneration; Male rats

Indexed keywords

3ALPHA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; ANDROSTANOLONE; AROMATASE; CYCLINE; ESTRADIOL; SEX HORMONE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; TRITIUM;

ANDROGEN METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ESTRADIOL BLOOD LEVEL; HORMONE BLOOD LEVEL; HORMONE METABOLISM; HORMONE TRANSPORT; INFERIOR CAVA VEIN; INJECTION; ISOTOPE LABELING; LIVER LEVEL; LIVER REGENERATION; LIVER RESECTION; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RADIOIMMUNOASSAY; RAT; TESTOSTERONE BLOOD LEVEL;

EID: 0035065778     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(00)00125-X     Document Type: Article

References (46)

1. Testosterone: A major determinant of extragenital sexual dimorphism
2. The effect of testosterone on liver healing after partial hepatectomy
3. The effect of sex and of testosterone on toxic liver damage
4. Complete liver regeneration in one-stage 90% hepatectomized rats treated with testosterone
5. Mechanisms of androgen actions
6. Changes produced by testicular hormone in normal and in castrated rats
7. Sex hormone-related functions in regenerating rat liver
8. Regenerating rat liver: Correlations between estrogen receptor localization and deoxyribonucleic acid synthesis
9. Estradiol and testosterone levels in patients undergoing partial hepatectomy: A possible signal for hepatic regeneration?
10. Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major liver resections
11. Estrogen and Androgen receptors in liver: Their role in liver disease and regeneration
12. Hepatic regeneration: Effect of age, sex hormone status, prolactin, and cyclosporine
13. Biological actions of androgens
14. Rat liver 3α-hydroxysteroid dehydrogenase
15. Androstanediol glucuronide production in human liver, prostate, and skin. Evidence for the importance of the liver in 5α-reduced androgen metabolism
16. Restoration of the liver of the white rat following partial surgical removing
17. Growth kinetic study of human hepatocellular carcinoma using proliferating cell nuclear cell antigen and Lewis Y antigen: Their correlation with transforming growth factor-α and β1
18. Optical microscope system for standerdized cell measurements and analyses
19. Quantification of endogenous testosterone and dihydrotestosterone and their possible intracellular determinants in various tissue of the male guinea pig
20. Hepatic regeneration
21. Relation of estrogen and its receptor to rat liver growth and regeneration
22. Chemical induction of hepatic neoplasia
23. Biochemical, pathological, and genetic aspects of spontaneous mouse hepatoma
24. Distant tumors produced by 2-amino-and 2-acetyl-aminofluorene
25. The effect of gonadectomy on the development of hepatomas induced by urethane
26. Early stages of N-2-fluorenylacetate-induced hepatocarcinogenesis in male and female rats and effect of gonadectomy on liver neoplastic conversion and neoplastic development
27. Risk factors in development of hepatocellular carcinoma in cirrhosis: Prospective study of 613 patients
28. Androgen receptor in rat liver: Characterization and separation from a male-specific estrogen-binding protein
29. Effect of androgens and their manipulation on cell growth and androgen receptor (AR) levels in AR-positive and -negative human hepatocellular carcinoma
30. Effect of castration and androgen replacement on tumor growth of human hepatocellular carcinoma in nude mice
31. Tissue distribution and kinetic characteristics of rat steroid 5α-reductase isozymes
32. Genetic and pharmacological evidence for more than one human steroid 5α-reductase
33. Effect of liver regeneration on hepatic cytochrome P450 isozymes and serum sex steroids in male rats
34. Oestradiol formation from testosterone by continuously cultured human breast cancer cells
35. Aromatization of testosterone and oestrogen receptor levels in human breast cancer
36. Conversion of androgens to estrogens in cirrhosis of the liver
37. An evaluation of the respective roles of portosystemic shunting and portal hypertension in rats upon the production of gonadal dysfunction in cirrhosis
38. Quantitative studies of testicular atrophy following portacaval shunt in rats
39. Peripubertal androgen imprinting of rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase: Pretranslational regulation and impact on microsomal drug activation
40. Photoaffinity labeling of steroid 5 alpha-reductase of rat liver and prostate microsomes
41. Increased hepatic androgen receptor expression in female rats during diethylnitrosamine liver carcinogenesis
42. Promoting effect of estrogen on regeneration of the liver transplanted to an ectopic site in mice
43. The effect of estrogen and tamoxifen on hepatocyte proliferation in vivo and in vitro
44. Role of estrogens as promotors of hepatic neoplasia
45. Estrogen induction of hepatocellular carcinomas in Armenian hamsters
46. Androgen receptor: An overview