Integration of amplified BCR/ABL fusion genes into the short arm of chromosome 17 as a novel mechanism of disease progression in chronic myeloid leukemia

Genes Chromosomes and Cancer

Volumn 31, Issue 1, 2001, Pages 10-14

  Metzke Heidemann, Simone ^a   Harder, Lana ^a   Gesk, Stefan ^a   Schoch, Robert ^a   Jenisch, Stefan ^a   Grote, Werner ^a   Siebert, Reiner ^a   Schlegelberger, Brigitte ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN;

ADULT; ARTICLE; CASE REPORT; CHROMOSOME 17; CHROMOSOME ARM; CHROMOSOME BANDING PATTERN; CHRONIC MYELOID LEUKEMIA; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE AMPLIFICATION; HUMAN; LEUKEMOGENESIS; MALE; MONOSOMY; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; BLAST CRISIS; CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 17; CYTOGENETIC ANALYSIS; DISEASE PROGRESSION; FEMALE; FUSION PROTEINS, BCR-ABL; GENE AMPLIFICATION; GENES, ABL; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, CHRONIC; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0035064686     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.1112     Document Type: Article

References (20)

1. c-abl and bcr are rearranged in a Ph-negative CML patient
2. The c-abl, bcr and C lambda genes are amplified in a cell line but not in the uncultured cells from a patient with chronic myelogenous leukemia
3. High incidence of a second bcr/abl fusion in chronic myeloid leukemia revealed by interphase cytogenetic analysis on blood and bone marrow smears
4. A study of prognostic factors in blast crisis of Philadelphia chromosome-positive chronic myelogenous leukemia
5. Translocation of bcr to chromosome 9: A new cytogenetic variant detected by FISH in two Ph-negative, bcr-positive patients with chronic myeloid leukemia
6. Molecular cytogenetics of chronic myeloid leukemia with atypical t(6;9) (p23;q34) translocation
7. Chronic myelogenous leukemia: A multivariate analysis of the associations of patient characteristics and therapy with survival
8. Chronic myelogenous leukemia in blast crisis
9. ABL amplification in a patient with lymphoid blast crisis of chronic myelogenous leukemia
10. A rapid method for PCR amplification of DNA directly from cells fixed in Carnoy's fixative
11. Detection of BCR/ABL genes in acute lymphoblastic leukemia by polymerase chain reaction
12. Classical and molecular cytogenetics of tumor cells
13. Glass slide smears are a suitable source for RT-PCR-based analysis of chromosomal aberrations in leukemias
14. Karyotype evolution of Ph positive chronic myelogenous leukemia patients relapsed in advanced phases of the disease after allogeneic bone marrow transplantation
15. Prognostic significance of additional cytogenetic abnormalities at diagnosis of Philadelphia chromosome-positive chronic granulocytic leukemia
16. Duplication of chromosome 9 carrying a bcr/abl chimeric gene in Philadelphia chromosome negative chronic myeloid leukemia
17. Frequent jumping translocation of chromosomal segments involving the ABL oncogene alone or in combination with CD3-MLL genes in secondary leukemias
18. Extensive amplification of bcr/abl fusion genes clustered on three marker chromosomes in human leukemic cell line K-562
19. Variant Ph-translocation t(9;17)(q34.2-3;q21.3) with colocalization of the BCR and ABL genes on chromosome 9 in chronic myeloid leukemia