Biological evaluation of the pollution of rivers flowing into Tokyo Bay with the 7-ethoxycoumarin O-deethylase (ECOD) activity induced by river sediment extracts in HepG2 cells

Journal of Health Science

Volumn 47, Issue 2, 2001, Pages 118-122

  Nito, S ^a   Todoroki, N ^a   Misumi, M ^a   Nakahama, T ^a   Inouye, Y ^a  

^a TOHO UNIVERSITY   (Japan)

Author keywords

7 ethoxycoumarin O deethylase; AhR; CYP1A1; HepG2 cells; River sediment

Indexed keywords

7 ETHOXYCOUMARIN DEETHYLASE; POLYCYCLIC AROMATIC HYDROCARBON;

ARTICLE; CELL STRAIN HEPG2; CYTOTOXICITY; DRUG ACTIVITY; HUMAN; HUMAN CELL; JAPAN; RIVER; SPECTROFLUOROMETRY; WATER POLLUTION; WATER SAMPLING;

ARA;

EID: 0035064333     PISSN: 13449702     EISSN: None     Source Type: Journal    
DOI: 10.1248/jhs.47.118     Document Type: Article

References (9)

1. Induction of cytochrome P450 in Hep G2 cells and mutagenicity of extracts of sedeiment from a waste disposal site near Osaka, Japan
2. Optimization of the Ames/Salmonella mutagenicity assay for use with extracts of aquatic sediments
3. A comparison of the Ames assay and mutatox in assessing the mutagenic potential of contaminated dredged sediment
4. The influence of sediment extract fractionation methods on bioassay results
5. Potency of various polycyclic aromatic hydrocarbons as inducers of CYP1A1 in rat hepatocyte cultures
6. Biochemical screening of highly toxic aromatic contaminants in river sediment and comparison of sensitivity of biological model systems
7. The effect of 1,2,3,4-tetrachlorodibenzo-p-dioxin on drug-metabolizing enzymes in the rat liver
8. Comparative study of CYP1A1 induction by 3-methylcholanthrene in various human hepatic and epidermal cell types
9. Induction of cytochrome P450-dependent monooxygenase in serum-free cultured Hep G2 cells