The hormonal milieu in early stages of bone cell differentiation modifies the subsequent sex-specific responsiveness of the developing bone to gonadal steroids

Journal of Bone and Mineral Research

Volumn 16, Issue 5, 2001, Pages 823-831

  Berger, E ^a   Bleiberg, I ^b   Weisman, Y ^a   Lifschitz Mercer, B ^a   Leider Trejo, L ^a   Harel, A ^a,c   Kaye, A M ^d   Somjen, D ^a  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c Deceased   (Israel)

^d WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Androgens; Bone; Bone marrow; Cartilage; Creatine kinase; Estrogen; Implants; Vitamin D

Indexed keywords

ANDROSTANOLONE; CREATINE KINASE BB; DNA; ESTRADIOL; SEX HORMONE; VITAMIN D;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MALFORMATION; BONE MARROW TRANSPLANTATION; CARTILAGE; CASTRATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA SYNTHESIS; ECTOPIC TISSUE; ENZYME ACTIVITY; FEMALE; GONADECTOMY; HORMONAL REGULATION; MALE; MESENCHYME; MOUSE; NONHUMAN; SEX DIFFERENCE; VITAMIN D DEFICIENCY;

24,25-DIHYDROXYVITAMIN D 3; ANIMALS; BONE AND BONES; BONE MARROW TRANSPLANTATION; CALCITRIOL; CARTILAGE, ARTICULAR; CELL DIFFERENTIATION; CREATINE KINASE; DIHYDROTESTOSTERONE; ESTRADIOL; FEMALE; MALE; MICE; MICE, INBRED C57BL; OSTEOBLASTS; TOOTH DEMINERALIZATION;

EID: 0035059476     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.5.823     Document Type: Article

References (31)

1. Direct and sex specific stimulation by sex steroids of creatine kinase activity and DNA synthesis in rat bone
2. Regulation of proliferation of rat cartilage and bone by sex steroid hormones
3. Stimulation of creatine kinase specific activity in human osteoblast and endometrial cells by estrogens and anti-estrogens and its modulation by calciotropic hormones
4. Age dependence and modulation by gonadectomy of the sex-specific response of rat diaphyseal bone to gonadal steroids
5. Sex specific response of bone cells to gonadal steroids: Modulation in perinatally androgenized females and testicular feminized male rats
6. Modulation by vitamin D status of the responsiveness of rat bone to gonadal steroids
7. Hormonal stimulation of bone cell proliferation
8. Reciprocal modulation by sex steroids and calciotrophic hormones of skeletal cell proliferation
9. Dissociative extraction and reconstruction of extracellular matrix components involved in local bone differentiation
10. Collaboration between collagenous matrix and osteogenin is required for bone induction
11. Growth factors in bone matrix
12. Transforming growth factor-beta and remodeling of bone
13. Bone repair induced by bone morphogenetic protein in ulnar effects in dogs
14. Recombinant bone morphogenetic protein-2 enhances bone healing aided by osteopromotive e-PTFE membranes: An experimental study in rats
15. Responsiveness of clonal limb bud cell lines to bone morphogenetic protein-2 reveals a sequential relationship between cartilage and bone cell phenotypes
16. IgG monoclonal antibodies that inhibit osteoinductivity of human bone matrix-derived proteins (hBMP/NCP)
17. Radiographical and biochemical study of demineralized bone matrix implanted into a bone defect of rat femurs with and without bone marrow
18. Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factor
19. Studies on marrow histogenesis
20. Transplantation of marrow to extramedullary sites
21. Precursor cells of mechanocytes
22. Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo
23. 24R,25-Dihydroxy vitamin D stimulates creatine kinase BB activity in chick cartilage cells in culture
24. The effects of 24R,25-dihydroxycholecalciferol and 1,25-dihydroxycholecalciferol on ornithine decarboxilase activity and on DNA synthesis in the epiphysis and diaphysis of rat bone and in the duodenum
25. Identification of the major component of the "estrogen induced protein" of rat uterus as the BB isozyme of creatine kinase
26. Dissociative extraction and reconstruction of extracellular matrix components involved in local bone differentiation
27. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
28. Estrogen binding, receptor mRNA and biological response in osteoblast-like osteosarcoma cells
29. Skeletal site-dependent expression of the androgen receptor in human osteoblastic cell populations
30. An estrogen stimulated 1,25-dihydroxy-vitamin D receptor in rat uterus