Mutagenesis of key residues identifies the connection subdomain of HIV-1 reverse transcriptase as the site of inhibition by heme

European Journal of Biochemistry

Volumn 268, Issue 4, 2001, Pages 925-931

  Argyris, Elias G ^a   Vanderkooi, Jane M ^b   Paterson, Yvonne ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Connection subdomain; Heme; HIV 1; Metalloporphyrins; Reverse transcriptase inhibition

Indexed keywords

HEME; RNA DIRECTED DNA POLYMERASE;

ARTICLE; BINDING AFFINITY; BINDING SITE; ENZYME INHIBITION; ENZYME PURIFICATION; FLUORESCENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

HEME; HIV-1 REVERSE TRANSCRIPTASE; METALLOPORPHYRINS; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OLIGOPEPTIDES; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE INHIBITORS; TRYPTOPHAN;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

EID: 0035059408     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.01944.x     Document Type: Article

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