Antipsychotic treatment induces alterations in dendrite- and spine-associated proteins in dopamine-rich areas of the primate cerebral cortex

Biological Psychiatry

Volumn 49, Issue 1, 2001, Pages 1-12

  Lidow, Michael S ^a   Song, Zan Min ^a   Castner, Stacy A ^a   Allen, Patrick B ^a   Greengard, Paul ^a   Goldman Rakic, Patricia S ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

Antipsychotic drugs; Dendrite; Microtubule associated protein 2; Spine; Spinophilin; Synapse; Synaptophysin

Indexed keywords

BRAIN PROTEIN; CYTOSKELETON PROTEIN; DOPAMINE; HALOPERIDOL; MICROTUBULE ASSOCIATED PROTEIN 2; NEUROLEPTIC AGENT; SPINOPHILIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; BRAIN NERVE CELL; BRAIN REGION; CONTROLLED STUDY; CYTOSKELETON; DENDRITE; DENDRITIC SPINE; DOSE RESPONSE; FEMALE; LONG TERM CARE; MENTAL DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; RHESUS MONKEY; SCHIZOPHRENIA; SYNAPSE VESICLE;

ANIMALS; ANTIPSYCHOTIC AGENTS; BLOTTING, NORTHERN; CEREBRAL CORTEX; DENDRITES; DOPAMINE; FEMALE; HALOPERIDOL; MACACA MULATTA; MICROFILAMENT PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; NEURONS; PHOSPHORYLATION; SYNAPTOPHYSIN;

EID: 0035058055     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(00)01058-1     Document Type: Article

References (95)

1. Mutual protection of microtubule-associated protein 2 (MAP2) and cyclic AMP-dependent protein kinase II against mu-calpain
2. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines
3. Ultrastructural features of cerebral synapses in schizophrenic patients
4. Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia
5. The biochemistry of neuro-transmitter secretion
6. Synaptic rearrangements in medial prefrontal cortex of haloperidol-treated rats
7. Regional and laminar distribution of the dopamine and serotonin innervation in the in the macaque cerebral cortex: A radioautoradiographic study
8. Haloperidol effect on intracellular signals system coupled to alpha1-adrenergic receptor in rat cerebral frontal cortex
9. The effects of haloperidol and clozapine on extracellular GABA levels in the prefrontal cortex of the rat: An in vivo microdialysis study
10. Neuronal and glial cytoskeleton
11. Dendritic spine density and LTP induction in cultured hippocampal slices
12. Alterations in hippocampal non-phosphorylated MAP2 protein expression in schizophrenia
13. 3H]ifenprodil binding in rat brain
14. Postmortem studies of the hippocampal formation in schizophrenia
15. Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia
16. Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography
17. Chronic haloperidol treatment differentially affects the expression of synaptic and neuronal plasticity-associated genes
18. Synaptobrevin binding to synaptophysin: A potential mechanism for controlling the exocytotic fusion machine
19. Reduced density on cerebral cortical pyramidal neurons in schizophrenia
20. Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia. Regional and diagnostic specificity
21. Phosphorylation of microtubule-associated protein 2 at distinct sites by calmodulin-dependent and cyclic-AMP-dependent kinases
22. The physiological approach: Functional architecture of working memory and disordered cognition in schizophrenia
23. The "psychic" neuron of the cerebral cortex
24. Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2
25. The neuropathology of schizophrenia. A critical review of the data and their interpretation
26. Dopamine receptors: Regulation of protein phosphorylation
27. Synaptic and plasticity-associated proteins in anterior frontal cortex in severe mental illness
28. Characterization of a synaptic antigen of interest in neuropsychiatric illness
29. Seasonal effects on ovarian folliculogenesis in rhesus monkeys
30. Calpain-mediated proteolysis pf microtubule-associated protein 2 (MAP2) is inhibited by phosphorylation by cAMP-dependent protein kinase but not by CA2+/calmoduline-dependent protein kinase II
31. The role of microtubule-associated protein 2 (MAP2) in neuronal growth, plasticity, and degeneration
32. Effects of haloperidol on cyclic AMP and inositol triphosphate in rat striatum in vivo
33. Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophrenia: A possible neurochemical basis for "hypofrontality"
34. Dopamine-sensitive adenyl cyclase: Possible role in synaptic transmission
35. Neurite elongation is blocked if microtubules polymerization is inhibited in PC12 cells
36. The effect of chronic haloperidol treatment on dendritic spines in the rat striatum
37. The effect of haloperidol on synaptic plasticity in rat medial prefrontal cortex
38. Synaptic plasticity in rat medial prefrontal cortex under haloperidol treatment produced behavioral sensitivity
39. Chronic haloperidol treatment increased calcium-dependent phosphorylation in rat striatum
40. Downregulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs
41. A common action of clozapine, haloperidol and remoxipride on D1-and D2-dopamine receptors in the primate cerebral cortex
42. Differential regulation of D2 and D4 dopamine receptor mRNAs in the primate cerebral cortex vs. neostriatum: Effects of chronic treatment with typical and atypical antipsychotic drugs
43. 3H]raclopride
44. A case for cerebral cortex as a common site of action by antipsychotic medications
45. Neurotransmitter regulation of neuronal outgrowth, plasticity and survival
46. Role of microtubule-associated proteins in the control of microtubule assembly
47. Cell adhesion molecules, CREB, and the formation of new synaptic connections
48. Quantitative immunohistochemistry of synaptophysin in human neocortex: An alternative method to estimate density of presynaptic terminals in paraffin sections
49. Effects of haloperidol and clozapine on the density of "perforated" synapses in caudate, nucleus accumbens, and medial prefrontal cortex
50. Effects of long-term treatment with desipramine on microtubule proteins in rat cerebral cortex
51. Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP resdponse element binding protein
52. Effects of chronic haloperidol treatment on synaptic protein mRNAs in the rat brain
53. The effect of chlorpromazine and haloperidol on second messenger system related to adrenergic receptors
54. Haloperidol increases prolactin release and cyclic AMP formation in vitro: Inverse agonism at dopamine D2 receptors?
55. Long-term neuroleptic treatments counteract dopamine D2 agonist inhibition of adenylate cyclase but do not affect pertussis toxin ADP-rybosylation in the rat brain
56. Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET
57. Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia
58. Serotonin 5HT2A receptors: Molecular biology and mechanisms of regulation
59. Localized changes in GABA receptor-gated chloride channel in rat brain after long-term haloperidol: Relation to vacuous chewing movements
60. Dopamine receptor in schizophrenia
61. Tardive dyskinesia, dopamine receptors, and neuroleptic damage to cell membranes
62. Atypical neuroleptics: Role of multiple receptors, endogenous dopamine, and receptor linkage
63. Dopamine receptor sequences. Therapeutic levels of neuroleptics accupy D2 receptors, clozapine occupies D4
64. Increased volume and glial density in primate prefrontal cortex associated with chronic antipsychotic drug exposure
65. Abnormally high neuronal density in the schizophrenic cortex
66. Respective roles of neurofilaments, microtubules, MAP1B and tau in neurite outgrowth and stabilization
67. Cyclic AMP-dependent endogenous phosphorylation of a microtubule-associated protein
68. Association of D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein
69. Calcium/phospholipid-dependent kinase recognized sites in microtubule-associated protein 2 which are phosphorylated in living brain and are not accessible to other kinases
70. Numerous phosphates of microtubule-associated protein in living rat brain
71. Structural changes in the neuropil of the frontal cortex in schizophrenia
72. Ultrastructural alterations of synaptic contactes and astrocytes in postmortem caudate nucleus of schizophrenic patients
73. Morphometric study of synaptic patterns in the rat caudate nucleus and hippocampus under haloperidol treatment
74. The effects of chronic haloperidol administration on GABA-immunoreactive axon terminals in rat medial prefrontal cortex
75. Evidence for ultrastructural changes in cortical axodendritic synapses following long-term treatment with haloperidol or clozapine
76. Multisite phosphorylation of microtubule-associated protein 2 (MAP2) in rat brain: Peptide mapping distinguishes between cyclic AMP-, calcium/calmodulin-, and calcium/phospholipid-regulated phosphorylation mechanisms
77. A cytoarchitectural study of the prefrontal area of the macaque monkey
78. Menstrual cycle characteristics of seasonally breeding rhesus monkeys
79. Cyclic AMP-dependent protein kinase from skeletal muscle and liver
80. The frontal lobes and schizophrenia
81. Antagonism of N-methyl-D-aspartate receptors by σ site ligands: Potency, subtype-selectivity and mechanisms of inhibition
82. Molecular structure and function of microtubule-associated proteins
83. Elimination of neurons from the rhesus monkey's lateral geniculate nucleus during development
84. Three-dimentional counting: An accurate and direct method to estimate numbers of cells in sectioned material
85. Characterization of the dopaminergic innervation of the primate frontal cortex using a dopamine-specific antibody
86. +2-dependent threonine phosphorylation of myosin heavy chain in rat pancreatic islets and RINm5F cells
87. Axon growth: Role of microfilaments and microtubules
88. Protein phosphatase 1 modulation of neostriatal AMPA channels: Regulation by DARPP-32 and spinophilin
89. Dopamine receptor stimulation decreases cytosolic gamma protein kinase C immunoreactivity in rat hippocampal slices: Evidence for increased Ca(2+)-dependent proteolysis