Expression of the RB protein, allelic imbalance of the RB gene and amplification of the CDK4 gene in metaplasias, dysplasias and carcinomas in Barrett's oesophagus

Anticancer Research

Volumn 21, Issue 1 A, 2001, Pages 387-392

  Sarbia, M ^a   Tekin, U ^a   Zeriouh, M ^a   Donner, A ^a   Gabbert, H E ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Barrett's oesophagus; CDK4; Loss of heterozygosity; RB

Indexed keywords

RETINOBLASTOMA PROTEIN;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; BARRETT ESOPHAGUS; CARCINOGENESIS; CLINICAL ARTICLE; DYSPLASIA; ESOPHAGUS CARCINOMA; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION; HETEROZYGOSITY LOSS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METAPLASIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; ADULT; AGED; BARRETT ESOPHAGUS; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; EPITHELIUM; ESOPHAGEAL NEOPLASMS; FEMALE; GENE AMPLIFICATION; GENES, RETINOBLASTOMA; GENETIC MARKERS; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; MALE; METAPLASIA; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; RETINOBLASTOMA PROTEIN; TUMOR MARKERS, BIOLOGICAL;

EID: 0035056643     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Barrett's esophagus, dysplasia, and adenocarcinoma
2. Barrett's esophagus
3. The columnar-lined esophagus, intestinal metaplasia, and Norrnan Barrett
4. Observer variation in the iagnosis of dysplasia in Barrett's esophagus
5. Dysplasia and aneuploidy as markers of malignant degeneration in Barrett's esophagus
6. High-grade dysplasia in Barrett's esophagus
7. Unrestricted cell cycling and cancer
8. Mutations of cell cycle regulators
9. Recent developments in the molecular characterization of Barrett's esophagus
10. Cancer cell cycles
11. Tumor suppressor genes
12. Role of the retinoblastoma protein in the pathogenesis of human cancer
13. Altered expression of the retinoblastoma gene product: Prognostic indicator in bladder cancer
14. Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis
15. Altered retinoblastoma protein expression and prognosis in early-stage non-small cell lung carcinoma
16. Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis: A review
17. Allelotype analysis of oesophageal adenocarcinoma: Loss of heterozygosity occurs at multiple sites
18. Separate amplified regions encompassing CDK4 and MDM2 in human sarcomas
19. Complexity of 12q 13-22 amplicon in liposarcoma: Microsatellite repeat analysis
20. Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation
21. CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines
22. CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas
23. Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase 4 (CDK4) and CDK2 in human esophageal squamous cell carcinoma
24. Expression of bcl-2 and amplification of c-myc are frequent in basaloid squamous cell carcinomas of the esophagus
25. Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis
26. Barrett's oesophagus: Microsatellite analysis provides evidence to support the proposed metaplasia-dysplasia-carcinoma sequence
27. Retino-blastoma protein (pRB) expression and prognosis in squamous cell carcinomas of the esophagus
28. Lack of nuclear RB protein staining in G0/middle G1 cells: Correlation to changes in total RB protein level
29. Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagus
30. Infrequent alterations of the p16INK4A gene in liver cancer