Disruption of the genes for clpXP protease in Salmonella enterica serovar Typhimurium results in persistent infection in mice, and development of persistence requires endogenous gamma interferon and tumor necrosis factor alpha

Infection and Immunity

Volumn 69, Issue 5, 2001, Pages 3164-3174

  Yamamoto, T ^a   Sashinami, H ^a   Takaya, A ^a   Tomoyasu, T ^a   Matsui, H ^a   Kikuchi, Y ^a   Hanawa, T ^a   Kamiya, S ^a   Nakane, A ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HYDROGEN PEROXIDE; PARAQUAT; PROTEINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTERIAL VIRULENCE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE DISRUPTION; GENE INSERTION; GENE MUTATION; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; SALMONELLA ENTERICA; SALMONELLOSIS; STRESS;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CHROMOSOME MAPPING; ENDOPEPTIDASE CLP; ESCHERICHIA COLI PROTEINS; INTERFERON TYPE II; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SALMONELLA INFECTIONS, ANIMAL; SALMONELLA TYPHIMURIUM; SERINE ENDOPEPTIDASES; TUMOR NECROSIS FACTOR-ALPHA; VIRULENCE;

EID: 0035055316     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.5.3164-3174.2001     Document Type: Article

References (70)

1. Salmonella typhimurium loci involved in survival within macrophages
2. r mice: Functional mviA results in avirulence; mutant (nonfunctional) mviA results in virulence
3. The primary effect of the lty locus is on the rate of growth of Salmonella typhimurium that are relatively protected from killing
4. Bacterial resistance to complement killing mediated by Ail protein of Yersinia enterocolitica
5. Induction of Salmonella stress proteins upon infection of macrophages
6. Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model
7. Salmonella spp. are cytotoxic for cultured macrophages
8. The product of the lon (capR) gene in Escherichia coli is the ATP-dependent protease La
9. Consensus sequence of Escherichia coli heat-shock gene promoters
10. Salmonella typhimurium deletion mutants lacking adenylate cyclase and cyclic AMP receptor protein are avirulent and immunogenic
11. Type III secretion by Salmonella typhimurium does not require contact with a eukaryotic host
12. Alteration of the synthesis of the Clp ATP-dependent protease affects morphological and physiological differentiation in Streptomyces
13. Characterization of porin and ompR mutants of a virulent strain of Salmonella typhimurium: ompR mutants are attenuated in vivo
14. The alternative sigma factor katF (rpoS) regulates Salmonella virulence
15. Mutants of Salmonella typhimurium that cannot survive within the macrophages
16. Molecular and cellular mechanisms of Salmonella pathogenesis
17. How Salmonella survive against the odds
18. ClpP participates in the degradation of misfolded protein in Lactococcus lactis
19. The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes
20. Proteases and their targets in Escherichia coli
21. ClpX, an alternative subunit for the ATP-dependent Clp protease of Escherichia coli
22. Systemic infection of mice by wild-type but not Spv 2 Salmonella typhimurium is enhanced by neutralization of gamma interferon and tumor necrosis factor alpha
23. Trigger factor depletion or overproduction causes defective cell division but does not block protein export
24. Specific purpose plasmid cloning vectors. I. Low copy number, temperature-sensitive, mobilization-defective pSC101-derived containment vectors
25. Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding components of the type III secretion apparatus of Salmonella pathogenicity island 2
26. Simultaneous identification of bacterial virulence genes by negative selection
27. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines
28. The Chlamydomonas chloroplast clpP gene contains translated large insertion sequences and is essential for cell growth
29. E, is critically important for the virulence of Salmonella typhimurium
30. The role of a stress-response protein in Salmonella typhimurium virulence
31. Capacity of recombinant gamma interferon to activate macrophages for Salmonella-killing activity
32. Homology in structural organization between E. coli ClpAP protease and the eukaryotic 26S proteasome
33. Uses of transposons, with emphasis on Tn10
34. The Salmonella typhimurium katF (rpoS) gene: Cloning, nucleotide sequence, and regulation of spvR and spvABCD virulence plasmid gene
35. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
36. Protein translocation channels in the proteasome and other proteases
37. Intracellular replication is essential for the virulence of Salmonella typhimurium
38. Selection of bacterial virulence genes that are specifically induced in host tissue
39. Serum TNF-α in mouse typhoid and enhancement of a Salmonella infection by anti-TNF-α antibodies on a Salmonella infection in the mouse model
40. Interleukin-12 required for control of the growth of attenuated aromatic-compound-dependent salmonellae in BALB/c mice: Role of gamma interferon and macrophage activation
41. Effect of antitumor necrosis factor alpha antibodies on histopathology of primary Salmonella infections
42. Proteases and protein degradation in Escherichia coli
43. Sequence and structure of ClpP, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli
44. Isolation of noninvasive mutants of gram-negative pathogens
45. A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence
46. A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion gene is absent from the corresponding region of the Escherichia coli K-12 chromosome
47. Progress and perspectives on the biology of heat shock proteins and molecular chaperone
48. ClpP of Bacillus subtilis is required for competence, development, motility, degradative enzyme synthesis, growth at high temperature and sporulation
49. Role of gamma interferon and tumor necrosis factor alpha in resistance to Salmonella typhimurium infection
50. Role of sigma factor RpoS in initial stages of Salmonella typhimurium infection
51. The protective role of endogenous cytokines in host resistance against an intragastric infection with Listeria monocytogenes in mice
52. Characterization of aromatic- and purine-dependent Salmonella typhimurium: Attenuation, persistence, and ability to induce protective immunity in BALB/c mice
53. Identification of a pathogenicity island required for Salmonella survival in host cells
54. The ClpP protein, a subunit of the Clp protease, modulates ail gene expression in Yersinia enterocolitica
55. A Brucella melitensis high temperature-requirement A (htrA) deletion mutant demonstrates a stress response defective phenotype in vitro and transient attenuation in the BALB/c mouse model
56. New insights into the ATP-dependent Clp protease: Escherichia coli and beyond
57. Murine salmonellosis studied by confocal microscopy: Salmonella typhimurium resides intracellularly inside macrophages and exerts a cytotoxic effect on phagocytosis in vivo
58. HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome
59. s) by ClpXP protease
60. Characterization of degP, a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperature
61. Development of a murine model of chronic Salmonella infection
62. Salmonella enterica serovar Typhimurium surA mutants are attenuated and effective live oral vaccines
63. Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: Role for IFN-gamma in activating apoptosis of hepatocytes
64. Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice
65. Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice
66. Analysis of the induction of general stress proteins of Bacillus subtilis
67. Effects of DksA and ClpP protease on sigma S production and virulence in Salmonella typhimurium
68. Identification and characterization of the Yersinia enterocolitica gsrA gene, which protectively responds to intracellular stress induced by macrophage phagocytosis and to extracellular environmental stress
69. Isolation of thermosensitive mutants of Yersinia enterocolitica by transposon insertion