Relationship of insulin sensitivity and ApoB levels to intra-abdominal fat in subjects with familial combined hyperlipidemia

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 21, Issue 4, 2001, Pages 567-572

  Purnell, Jonathan Q ^a,d   Kahn, Steven E ^b   Schwartz, Robert S ^c   Brunzell, John D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Apolipoproteins; Hyperlipidemia; Insulin resistance; Obesity; Visceral fat

Indexed keywords

APOLIPOPROTEIN B; CHOLESTEROL; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ABDOMEN; ADULT; AGED; ARTICLE; BODY FAT; BODY MASS; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE ASSOCIATION; FAMILIAL DISEASE; FEMALE; HUMAN; HYPERLIPIDEMIA; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; LIPOPROTEIN BLOOD LEVEL; MALE; OBESITY; PHENOTYPE; PRIORITY JOURNAL;

EID: 0035053666     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.21.4.567     Document Type: Article

References (50)

1. Hyperlipidemia in coronary heart disease, II: Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia
2. Inheritance of combined hyperlipoproteinemia: Evidence for a new lipoprotein phenotype
3. Family study of serum lipids and lipoproteins in coronary heart-disease
4. Myocardial infarction in the familial forms of hypertriglyceridemia
5. Association of coronary atherosclerosis with hyperapobetalipoproteinemia [increased protein but normal cholesterol levels in human plasma low density (β) lipoproteins]
6. Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia
7. Plasma triglyceride and LDL heterogeneity in familial combined hyperlipidemia
8. LDL physical and chemical properties in familial combined hyperlipidemia
9. Very low density lipoprotein overproduction in genetic forms of hypertriglyceridemia
10. Kinetic bases of the primary hyperlipidemias: Studies of apolipoprotein B turnover in genetically defined subjects
11. Integrated regulation of very low density lipoprotein triglyceride and apolipoprotein B kinetics in man: Normolipemic subjects, familial hypertriglyceridemia and familial combined hyperlipidemia
12. Sources of inter-individual variation in the quantitative levels of apolipoprotein B in pedigrees ascertained through a lipid clinic
13. Lack of evidence for linkage between low-density lipoprotein subclass phenotypes and the apolipoprotein B locus in familial combined hyperlipidemia
14. Bimodality of plasma apolipoprotein B levels in familial combined hyperlipidemia
15. Familial combined hyperlipidemia and abnormal lipoprotein lipase
16. Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity
17. Regulatory mutations in the human lipoprotein lipase gene in patients with familial combined hyperlipidemia and coronary artery disease
18. Linkage of a candidate gene locus to familial combined hyperlipidemia: Lecithin:cholesterol acyltransferase on 16q
19. Inheritance of low-density lipoprotein subclass patterns: Results of complex segregation analysis
20. LDL particle size distribution: Results from the Framingham Offspring Study
21. Effect of gender, age, and lipid status on low density lipoprotein subfraction distribution: Results from the Framingham Offspring study
22. Low density lipoprotein subclass pattern and risk of myocardial infarction
23. Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions
24. The visceral adiposity syndrome in Japanese-American men
25. The dense LDL phenotype: Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men
26. Apolipoprotein, LDL subfraction, and insulin associations with familial combined hyperlipidemia in Utah patients with familial dyslipidemic hypertension
27. Defects of insulin action on fatty acid and carbohydrate metabolism in familial combined hyperlipidemia
28. Nonobese patients with familial combined hyperlipidemia are insulin resistant compared with their nonaffected relatives
29. Insulin resistance in patients with familial combined hyperlipidemia and coronary artery disease
30. A study of insulin resistance using the minimal model in nondiabetic familial combined hyperlipidemic patients
31. Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: A precursor defect for dyslipidemia?
32. Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic patients
33. Impaired fatty acid metabolism in familial combined hyperlipidemia: A mechanism associating hepatic apolipoprotein B overproduction and insulin resistance
34. Genetic predictors of FCHL in four large pedigrees: Influence of apoB level major locus predicted genotype and LDL subclass phenotype
35. Intra-abdominal fat is associated with decreased insulin sensitivity in healthy young men
36. Insulin sensitivity and serum triglyceride level in obese white and black women: Relationship to visceral and truncal subcutaneous fat
37. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B
38. Compositional differences of LDL particles in normal subjects with LDL subclass phenotype A and LDL subclass phenotype B
39. The insulin sensitivity index in man: Correlation between clamp-derived and IVGTT-derived values
40. Immunoassay of insulin: Two antibody systems
41. Quantitative estimation of insulin sensitivity
42. Abnormal body fat distribution detected by computed tomography in diabetic men
43. Hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 studied with a stable isotope technique in men with visceral obesity
44. Obesity and regional body-fat distribution in men: Separate and joint relationships to glucose tolerance and plasma lipoproteins
45. Metabolic and adipose risk factors for NIDDM and coronary disease in third-generation Japanese-American men and women with impaired glucose tolerance
46. Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia
47. Novel genes for familial combined hyperlipidemia
48. Genetic evidence from seven families that the apolipoprotein B gene is not involved in familial combined hyperlipidemia
49. Pedigree and sib-pain linkage analysis suggest the apo B gene is not the major gene influencing plasma apolipoprotein B levels