The guanylyl cyclase family at Y2K

Annual Review of Physiology

Volumn 63, Issue , 2001, Pages 215-233

  Wedel, B J ^a   Garbers, D L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Adenylyl cyclase; Cyclic GMP; Genetic diseases; Heat stable enterotoxins; Hypertension; Natriuretic peptides; Nitric oxide; Olfaction; Vision

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CARBON MONOXIDE; CYCLIC GMP; ENTEROTOXIN; GUANYLATE CYCLASE; GUANYLATE CYCLASE A; GUANYLATE CYCLASE B; GUANYLATE CYCLASE C; GUANYLATE CYCLASE D; GUANYLATE CYCLASE E; GUANYLATE CYCLASE F; GUANYLATE CYCLASE G; HEAT SHOCK PROTEIN 90; LIGAND; NITRIC OXIDE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE; UNCLASSIFIED DRUG;

CATALYSIS; DIARRHEA; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SUBUNIT; GENE DISRUPTION; GENE MUTATION; GENETIC DISORDER; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; LEBER CONGENITAL AMAUROSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RETINITIS PIGMENTOSA; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; GUANYLATE CYCLASE; HUMANS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; SIGNAL TRANSDUCTION;

EID: 0035052702     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.63.1.215     Document Type: Review

References (122)

1. A new form of guanylyl cyclase is preferentially expressed in rat kidney
2. Identification and characterization of a novel beta subunit of soluble guanylyl cyclase that is active in the absence of a second subunit and is relatively insensitive to nitric oxide
3. Studying the structure and regulation of soluble guanylyl cyclase
4. Soluble guanylate cyclase purified from bovine lung contains heme and copper
5. Functional properties of a naturally occurring isoform of soluble guanylyl cyclase
6. Functions of conserved cysteines of soluble guanylyl cyclase
7. Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclase
8. Soluble guanylyl cyclases in Caenorhabditis elegans: NO is not the answer
9. New insights on the functions of the guanylyl cyclase receptors
10. Guanylyl cyclases: Approaching year thirty
11. The natriuretic peptide family
12. Novel sites for expression of an Escherichia coli heat-stable enterotoxin receptor in the developing rat
13. Guanylyl cyclase-C is an N-linked glycoprotein receptor that accounts for multiple heat-stable enterotoxin binding proteins in the intestine
14. Structure and activity of OK-GC: A kidney receptor guanylate cyclase activated by guanylin peptides
15. Guanylin regulatory peptides: Structures, biological activities mediated by cyclic GMP and pathobiology
16. Guanylin peptides: Renal actions mediated by cyclic GMP
17. The cloning of a Caenorhabditis elegans guanylyl cyclase and the construction of a ligand-sensitive mammalian/nematode chimeric receptor
18. Guanylyl cyclase expression in specific sensory neurons: A new family of chemosensory receptors
19. The disulfide linkages and glycosylation sites of the human natriuretic peptide receptor-C homodimer
20. A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons
21. A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway
22. The membrane guanylyl cyclase, retinal guanylyl cyclase-1, is activated through its intracellular domain
23. GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy
24. The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2
25. Olfaction and odor discrimination are mediated by the C. elegans guanylyl cyclase ODR-1
26. Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATPase-like domain in Paramecium, Tetrahymena and Plasmodium
27. A guanylyl cyclase from paramecium with 22 transmembrane spans. Expression of the catalytic domains and formation of chimeras with the catalytic domains of mammalian adenylyl cyclases
28. Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum
29. Structure of the adenylyl cyclase catalytic core
30. Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsα GTPγS
31. Catalytic mechanism of the adenylyl and guanylyl cyclases: Modeling and mutational analysis
32. Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases
33. Expression of soluble guanylate cyclase: Catalytic activity requires two enzyme subunits
34. Expression of soluble guanylate cyclase activity requires both enzyme subunits
35. Structure, mechanism, and regulation of mammalian adenylyl cyclase
36. The interactions of adenylate cyclases with P-site inhibitors
37. Conversion of a guanylyl cyclase to an adenylyl cyclase
38. Characterization of particulate and soluble guanylate cyclases from rat lung
39. The hepatic adenylate cyclase system. II. Substrate binding and utilization and the effects of magnesium ion and pH
40. Two-metal-ion catalysis in adenylyl cyclase
41. Metal and metal-ATP interactions with brain and cardiac adenylate cyclases
42. Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase
43. The protein kinase domain of the ANP receptor is required for signaling
44. The photoreceptor guanylate cyclase is an autophosphorylating protein kinase
45. Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase
46. Jaks and STATs: Biological implications
47. Janus kinases and their role in growth and disease
48. Signalling through the JAK-STAT pathway in the developing brain
49. Regulation of the jak2 tyrosine kinase by its pseudokinase domain
50. Structural and functional basis for JAK3-deficient severe combined immunodeficiency
51. Retention of the speract receptor by isolated plasma membranes of sea urchin spermatozoa
52. Dephosphorylation of the guanylyl cyclase-A receptor causes desensitization
53. Protein kinase C-dependent desensitization of the atrial natriuretic peptide receptor is mediated by dephosphorylation
54. Dual role for adenine nucleotides in the regulation of the atrial natriuretic peptide receptor, guanylyl cyclase-A
55. Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor
56. Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptor
57. A constitutively "phosphorylated" guanylyl cyclase-linked atrial natriuretic peptide receptor mutant is resistant to desensitization
58. Reciprocal antagonism coordinates C-type natriuretic peptide and mitogen-signaling pathways in fibroblasts
59. A transmembrane guanylyl cyclase (DAF-11) and hsp90 (DAF-21) regulate a common set of chemosensory behaviors in Caenorhabditis elegans
60. Hsp90 & Co. - A holding for folding
61. Hsp90's secrets unfold: New insights from structural and functional studies
62. Adenine nucleotides are required for activation of rat atrial natriuretic peptide receptor/guanylyl cyclase expressed in a baculovirus system
63. Heat-stable enterotoxin activation of immunopurified guanylyl cyclase C. Modulation by adenine nucleotides
64. Domain-specific stabilization of photoreceptor membrane guanylyl cyclase by adenine nucleotides and guanylyl cyclase activating proteins (GCAPs)
65. Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor
66. Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90
67. Overlapping sites of tetratricopeptide repeat protein binding and chaperone activity in heat shock protein 90
68. Cardiac fibrosis in mice lacking brain natriuretic peptide
69. The molecular basis of hypertension
70. Salt-resistant hypertension in mice lacking the guanylyl cyclase-A receptor for atrial natriuretic peptide
71. Magnetic resonance imaging accurately estimates LV mass in a transgenic mouse model of cardiac hypertrophy
72. Hypertension associated with decreased testosterone levels in natriuretic peptide receptor-A gene-knockout and gene-duplicated mutant mouse models
73. The heart communicates with the kidney exclusively through the guanylyl cyclase-A receptor: Acute handling of sodium and water in response to volume expansion
74. A genetic model defines the importance of the atrial natriuretic peptide receptor (guanylyl cyclase-A) in the regulation of kidney function
75. Importance of disulfide bridges in the structure and activity of Escherichia coli enterotoxin ST1b
76. Guanylyl cyclase is a heat-stable enterotoxin receptor
77. Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II
78. Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice
79. Mice lacking the guanylyl cyclase C receptor are resistant to STa-induced intestinal secretion
80. Guanylyl cyclase receptors and guanylin-like peptides in reptilian intestine
81. Opossum kidney contains a functional receptor for the Escherichia coli heat-stable enterotoxin
82. Two membrane forms of guanylyl cyclase found in the eye
83. Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers
84. Disruption of a retinal guanylyl cyclase gene leads to cone-specific dystrophy and paradoxical rod behavior
85. Leber congenital amaurosis
86. Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis
87. A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype
88. Mutations in the retinal guanylate cyclase (RETGC-1) gene in dominant cone-rod dystrophy
89. A retGC-1 mutation in autosomal dominant cone-rod dystrophy
90. Autosomal dominant cone-rod retinal dystrophy (CORD6) from heterozygous mutation of GUCY2D, which encodes retinal guanylate cyclase
91. Mutations in the rod outer segment membrane guanylate cyclase in a cone-rod dystrophy cause defects in calcium signaling
92. Biochemical analysis of a dimerization domain mutation in RetGC-1 associated with dominant cone-rod dystrophy
93. A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1
94. Constitutive activation of photoreceptor guanylate cyclase by Y99C mutant of GCAP-1. Possible role in causing human autosomal dominant cone degeneration
95. Targeted disruption of the neuronal nitric oxide synthase gene
96. Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase
97. Neuronal and endothelial nitric oxide synthase gene knockout mice
98. Impaired liver regeneration in inducible nitric oxide synthase deficient mice
99. Hypertension in mice lacking the gene for endothelial nitric oxide synthase
100. Elevated blood pressures in mice lacking endothelial nitric oxide synthase
101. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3
102. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling
103. Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice
104. Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase: Contributions of NOS isoforms to blood pressure and heart rate control
105. Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase
106. Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension
107. Blood pressure and fluid-electrolyte balance in mice with reduced or absent ANP
108. Salt-sensitive hypertension in ANP knockout mice: Potential role of abnormal plasma renin activity
109. Chronic hypertension in ANP knockout mice: Contribution of peripheral resistance
110. Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice
111. Hypotension in transgenic mice expressing atrial natriuretic factor fusion genes
112. Hemodynamics in transgenic mice with overexpression of atrial natriuretic factor
113. Coronary vascular and endothelial reactivity changes in transgenic mice overexpressing atrial natriuretic factor
114. Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide
115. The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
116. The guanylyl cyclase-deficient mouse defines differential pathways of natriuretic peptide signaling
117. Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
118. Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner
119. Defective smooth muscle regulation in cGMP kinase I-deficient mice
120. Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice
121. Functional consequences of a rod outer segment membrane guanylate cyclase (ROS-GC1) gene mutation linked with Leber's congenital amaurosis
122. A nonsense mutation in the retinal specific guanylate cyclase gene is the cause of Leber congenital amaurosis in a large inbred kindred from Jordan