Characterization of an apolipoprotein E3 variant (Arg 145 → His) associated with mild hypertriglyceridemia

Annals of Clinical and Laboratory Science

Volumn 31, Issue 2, 2001, Pages 163-170

  Hidaka, H ^a   Tozuka, M ^a   Hidaka, E ^a   Yamauchi, K ^a   Ota, H ^a   Honda, T ^a   Katsuyama, T ^a  

^a SHINSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Apolipoprotein E; Heparin; Hypertriglyceridemia; Isoform; LDL receptor; Polymorphism; Variant

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; CHOLESTEROL; HEPARIN; LOW DENSITY LIPOPROTEIN RECEPTOR; SEPHAROSE; TRIACYLGLYCEROL;

ADULT; AGAR GEL ELECTROPHORESIS; AMINO ACID SUBSTITUTION; ARTICLE; CASE REPORT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HYPERTRIGLYCERIDEMIA; ISOELECTRIC FOCUSING; ISOELECTRIC POINT; MALE; MOLECULAR WEIGHT; PATHOGENESIS; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RECEPTOR AFFINITY;

ADULT; APOLIPOPROTEINS E; CHROMATOGRAPHY, AFFINITY; ELECTROPHORESIS, AGAR GEL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; HYPERTRIGLYCERIDEMIA; ISOELECTRIC FOCUSING; ISOELECTRIC POINT; MALE; PHENOTYPE; RECEPTORS, LDL; VARIATION (GENETICS);

RAPHIA FRATER;

EID: 0035051681     PISSN: 00917370     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Human apolipoprotein E: The complete amino acid sequence
2. Apolipoprotein E: Cholesterol transfer port protein with expanding role in cell biology
3. Remnant lipoprotein metabolism: Key pathways involving cell surface heparan sulfate proteo-glycans and apolipoprotein E
4. Hepatic uptake of chylomicron remnants
5. The LDL-receptor related protein, LRP, is an apolipo-proteinE-binding protein
6. Lipoprotein receptors and cholesterol homeostasis
7. Heparin sulfate proteoglycans participate in hepatic lipase and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoprotein
8. Human E apolipoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms
9. Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification
10. Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cystein-arginine interchange at a single site
11. Apoprotein (E-AII) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in high density lipoprotein subfraction
12. Apoprotein (E-AII) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo (E-AII) complex
13. Identification and characterization of apolipoprotein (AII-E2-AII) complex in human plasma lipoprotein
14. Identification of the disulfide-linked homodimer of apolipoprotein E3 in plasma
15. Overexpression of apolipoprotein E in transgenic mice: Marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia
16. Identification and characterization of a new variant of apolipoprotein E (apo E-Kochi)
17. Identification of an apoE variant and lipoprotein profile
18. The distribution and chemical composition of ultracentrifugally separated lipoprotein in human serum
19. Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipidemic subjects
20. Isothiocyanate compound as fluorescent labeling agents for immune serum
21. A simple, flow cytometric assay for functional LDL receptor using a fluorescent-labeled LDL, Dil-LDL
22. Genetic defects in lipoprotein metabolism: Elevation of atherogenic lipoproteins caused impaired catabolism
23. Type III hyperlipipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E
24. The plasma lecithins: Cholesterol acyl-transferase reaction
25. Cholesteryl ester and apolipoprotein E transfer between human high density lipoproteins and chylomicrons
26. High density lipoprotein subfractions isolated by heparin-Sepharose affinity chromatography and their role in cholesteryl ester transfer to very low density lipoproteins
27. Effects of diet on apoprotein E levels and on the apoprotein E subspecies in human plasma lipoproteins
28. Distribution of apolipoprotein E between free and A-II complexed forms in very-low- and high-density lipoproteins: Functional implications
29. Apolipoprotein E2-Heidelberg (Arg136→ Cys), a new variant of apolipoprotein E associated with incomplete dominance of type III hyperlipoproteinemia
30. Apolipoprotein E2-Christchurch (136Arg→ Ser). New variant of human apolipoprotein E in a patient with type III hyperlipoproteinemia
31. Identification of a new apolipoprotein E variant (E2 Arg142→ Leu) in type III hyperlipoproteinemia
32. The function characteristics of a human apolipoprotein E variant (Cys at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia
33. Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects
34. Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3′ (Arg136 → His): Association with mild dyslipidemia and double pre-β very low density lipoproteins
35. Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3
36. Interaction of plasma lipoproteins containing apolipoproteins B and E with heparin and cell surface receptors
37. The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding