Regional cerebral blood flow response to oral amphetamine challenge in healthy volunteers

Journal of Nuclear Medicine

Volumn 42, Issue 4, 2001, Pages 535-542

  Devous M D , Sr ^a   Trivedi, M H ^a   Rush, A J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Amphetamine challenge; Healthy volunteers; rCBF; SPECT

Indexed keywords

DEXAMPHETAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; IOFETAMINE I 123;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG DISTRIBUTION; DRUG RESPONSE; FEMALE; FRONTAL LOBE; GLUCOSE METABOLISM; HUMAN; MALE; MOTOR CORTEX; NORMAL HUMAN; PHARMACOLOGICAL STIMULATION; PREFRONTAL CORTEX; PRIORITY JOURNAL; SINGLE BLIND PROCEDURE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THALAMUS; THREE DIMENSIONAL IMAGING; VENTRAL TEGMENTUM; VISUAL CORTEX;

ADMINISTRATION, ORAL; ADULT; AMPHETAMINE; AMPHETAMINES; BRAIN; CEREBROVASCULAR CIRCULATION; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IODINE RADIOISOTOPES; MALE; RADIOPHARMACEUTICALS; REFERENCE VALUES; SINGLE-BLIND METHOD; TECHNETIUM TC 99M EXAMETAZIME; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0035051378     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Neurobiological bases for psychiatric disorders
2. Hormone response to methylamphetamine in depression: A new approach to the noradrenalin depletion hypothesis
3. Heterogeneity of amphetamine response in depressed patients
4. Reduced growth hormone responses to amphetamine in "endogenous" depressive patients
5. Growth hormone response to dextroamphetamine in depressed patients and normal subjects
6. Dextroamphetamine response as a possible predictor of improvement with tricyclic therapy in depression
7. Prediction of imipramine antidepressant response by a one-day d-amphetamine trial
8. Amphetamine-induced catecholamine activation in schizophrenia and depression
9. d-amphetamine-induced heterogeneous changes in psychotic behavior in schizophrenia
10. Response to apomorphine, amphetamine, and neuroleptics in schizophrenic subjects
11. Hormonal response to d-amphetamine in schizophrenia
12. Differential effects of amphetamine and neuroleptics on negative vs. positive symptoms in schizophrenia
13. Amphetamine increases prolactin but neither growth hormone nor beta-endorphin immunoreactivity in schizophrenic patients
14. Prediction of early relapse after pimozide discontinuation by response to d-amphetamine during pimozide treatment
15. Relationship between responses to dopamine agonists, psychopathology, neuroleptic maintenance in schizophrenic subjects
16. PET studies of cerebral function in major depression and obsessive compulsive disorder: The emerging prefrontal cortex consensus
17. Imaging brain function by single-photon emission computed tomography
18. Structured clinical interview for DSMIIIR (SCID). I. History and rationale
19. 133Xe SPECT
20. 123l: Validation by phantom studies
21. Effects of d- and l-amphetamine on local cerebral glucose utilization in the conscious rat
22. Effect of apomorphine on the relationship between local cerebral glucose utilization and local cerebral blood flow (with an appendix on its statistical analysis)
23. Accurate three-dimensional correlation of CT, PET and MR images of the brain
24. "CORT-EX": A program for quantitative analysis of brain SPECT data
25. Catecholamine uptake by synaptosomes in homogenates of rat brain: Stereospecificity in different areas
26. d- and l-amphetamine stereoisomers: Comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons
27. The role of dopamine in maintaining intracranial self-stimulation in the ventral tegmentum, nucleus accumbens, and prefrontal cortex
28. Destruction of dopaminergic terminals in nucleus accumbens: Effect on d-amphetamine self-administration
29. Dopamine autoreceptor subsensitivity: A mechanism common to the treatment of depression and the induction of amphetamine psychosis
30. Behavioral pharmacology of local anaesthetics: Reinforcing and discriminative stimulus effects
31. Differential effects of d- and l-amphetamine on behavior and on catecholamine disposition in dopamine and norepinephrine containing neurons of rat brain
32. Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, "pre-frontal" and "limbic" functions
33. Frontal-subcortical circuits in neuropsychiatric disorders
34. Role of the dopaminergic system in depression
35. Effects of amphetamine on local cerebral metabolism in normal and schizophrenic subjects as determined by positron emission tomography
36. Acute d-amphetamine challenge in schizophrenia: Effects on cerebral glucose utilization and clinical symptomatology
37. The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia
38. Dextroamphetamine enhances "neural network-specific" physiological signals: A positron-emission tomography rCBF study
39. Effects of acute stimulant medication on cerebral metabolism in adults with hyperactivity
40. Effects of intravenous dextroamphetamine on brain metabolism in adults with attention-deficit hyperactivity disorder (ADHD): Preliminary findings