Ethanol decreases expression of p21 and increases hyperphosphorylated pRb in cell lines of squamous cell carcinomas of the head and neck

Alcoholism: Clinical and Experimental Research

Volumn 25, Issue 4, 2001, Pages 496-501

  Hager, Gudrun ^a   Formanek, Michael ^a   Gedlicka, Claudia ^a   Knerer, Birgit ^a   Kornfehl, Johannes ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cell Cycle; Ethanol; p21

Indexed keywords

ALCOHOL; CYCLIN D1; PROTEIN P21; RETINOBLASTOMA PROTEIN;

ARTICLE; CANCER RISK; CARCINOGENESIS; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; HEAD CANCER; HUMAN; HUMAN CELL; IN VITRO STUDY; LARYNX CANCER; NECK CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SQUAMOUS CELL CARCINOMA;

EID: 0035049876     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2001.tb02241.x     Document Type: Article

References (39)

1. Alcohol inhibits cell mitosis in G2-M phase in cell cycle in a human lymphocytes in vitro study
2. Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control
3. Alcohol and cancer
4. Smoking and drinking in relation to oral and pharyngeal cancer
5. Effect of chronic alcohol consumption on the oral mucosa. A morphometric examination
6. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
7. The prognostic effect of tobacco and alcohol consumption in intra-oral squamous cell carcinoma
8. Ethanol causes accelerated G1 arrest in differentiating HL 60 cells
9. Cessation of alcohol drinking and risk of cancer of the oral cavity and pharynx
10. WAF1/CIP1 and prolongs G1 transition via a p53-independent pathway in human epithelial cells
11. Toward the primary prevention of cancer
12. Effects of acetaldehyde on cell regeneration and differentiation of the upper gastrointestinal tract mucosa
13. The role of ethanol in oncogenesis of the upper aerodigestive tract; Inhibition of DNA repair
14. PRAD- 1/Cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas
15. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK 4
16. Alcohol in the aetiology of upper aerodigestive tract cancer
17. Induction of the c-jun protooncogene by a protein kinase c-dependent mechanism during exposure of human epidermal keratinocytes to ethanol
18. Effects of ethanol treatment on proliferation and differentiation in a head and neck squamous cell carcinoma cell line
19. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity
20. An association of chronic alcohol consumption with morphological alterations of the laryngeal mucosa in rats
21. Effect of chronic alcohol consumption on the morphology of the oral mucosa
22. 1 block: Dose effects of short- and long-term ethanol exposure on cell cycle and cell functions
23. Alcohol acts to promote incidence of tumors
24. Retinoblastoma: Clues for human oncogenesis
25. 1/S cyclins and cyclin-dependent kinases characterize squamous cell carcinomas of the head and neck
26. Increased cell division as a cause of human cancer
27. Influence of ethanol on in vitro growth of human mammary carcinoma cell line MCF-7
28. DNA cleavage during ethanol metabolism: Role of superoxide radicals and catalytic iron
29. Cell proliferation and its evaluation in the colorectal mucosa: Effect of ethanol
30. Regulation of signal transduction and DNA fragmentation in thymocytes by ethanol
31. 1 cyclin-dependent kinases
32. Antibodies detecting abnormalities of the retinoblastoma susceptibility gene product (pp110RB) in osteosarcomas and synovial sarcomas
33. Enhancement of ethanol induced rectal mucosal hyper regeneration with age in F344 rats
34. Esophageal epithelial hyperproliferation following long-term alcohol consumption in rats: Effects of age and salivary gland function
35. Review article: The role of oncogenes, tumour suppressor genes and growth factors in oral squamous cell carcinoma: A case of apoptosis versus proliferation
36. Induction of epidermal growth factor receptor expression and mitogenesis by alcohol in human colon adenocarcinoma-derived Caco-2 cells
37. High salivary acetaldehyde after a moderate dose of alcohol in ALDH2-deficient subjects: Strong evidence for the local carcinogenic action of acetaldehyde
38. The retinoblastoma protein and cell cycle control
39. Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma