Oral repletion of iron induces free radical mediated alterations in the gastrointestinal tract of rat

Molecular and Cellular Biochemistry

Volumn 219, Issue 1-2, 2001, Pages 91-98

  Srigiridhar, K ^a   Nair, K Madhavan ^a,b   Subramanian, R ^a   Singotamu, L ^a  

^a NATIONAL INSTITUTE OF NUTRITION   (India)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Cell turnover; DNA damage; Free radical; GI tract; Iron deficiency; Rat; Ultrastructure

Indexed keywords

DNA; DRUG VEHICLE; FREE RADICAL; HYDROXYL GROUP; IRON; TRITIUM;

ABSORPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DNA SYNTHESIS; ELECTRON SPIN RESONANCE; ELECTROPHORESIS; FEMALE; GASTROINTESTINAL ABSORPTION; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL TRACT; INTESTINE BRUSH BORDER; IRON DEFICIENCY; IRON THERAPY; MEASUREMENT; MUCOSA CELL; NECROSIS; NONHUMAN; RAT; TIME; TISSUE INJURY; TRANSMISSION ELECTRON MICROSCOPY; TURNOVER TIME;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; DIETARY SUPPLEMENTS; DNA DAMAGE; DRUG INTERACTIONS; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTROPHORESIS, AGAR GEL; FEMALE; FREE RADICALS; HYDROGEN PEROXIDE; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; IRON; MICROSCOPY, ELECTRON; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, INBRED WKY;

ANIMALIA; TRITIUM;

EID: 0035047128     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011023111048     Document Type: Article

References (25)

1. Biology of disease: Free radicals and tissue injury
2. Iron deficiency: Contemporary scientific issues and international programmatic approaches
3. Evaluation of nutritional anemia prophylactic programme
4. Preventing and controlling iron deficiency anaemia through primary health care: A guide for health administers and programme managers
5. Effects of weekly iron supplementation on pregnant Indonesian women are similar to those of daily supplementation
6. The influence of previous iron intake on the estimation of bioavailability of Fe from a test meal given to rats
7. Protective effects of antioxidant enzymes and GSH in vivo on iron mediated lipid peroxidation in gastrointestinal tract of rat
8. Iron deficient intestine is more susceptible to peroxidative damage during iron supplementation in rats
9. AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition adhoc writing committee on the reformulation of the AIN-76A rodent diet
10. Preparation and properties of mucosal epithelial cells isolated from small intestine of the chicken
11. Human lactoferrin stimulates thymidine incorporation into DNA of rat crypt cells
12. Effect of nuclear localisation of large tumour antigen on growth potential of SV40-transformed cells
13. A new fluorometric method for RNA and DNA determination
14. Zinc inhibits UV radiation-induced apoptosis but fails to prevent subsequent cell death
15. Simulation of multiple isotropic spin-trap EPR spectra
16. A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy
17. Apoptosis: A different type of cell death
18. Damage to the bases in DNA induced by hydrogen peroxide and ferric ion chelates
19. A simple method for determining epithelial cell turnover in small intestine
20. Further studies in rats on the influence of iron intake on the estimation of bioavailability of Fe
21. Intermittent iron supplementation in Chinese pre-school children is efficient and safe
22. A WHO collaborative study on iron supplementation in Burma and in Thailand
23. The pathology of hepatic iron overload: A free radical mediated process?
24. Direct evidence for in vivo hydroxyl - Radical generation in experimental iron overload: An ESR spin-trapping investigation
25. Supplementation with α-tocopherol or a combination of α-tocopherol and ascorbic acid protects the gastrointestinal tract of iron deficient rats against iron induced oxidative damage during iron repletion