The positive inotropic and chronotropic effects of evodiamine and rutaecarpine, indoloquinazoline alkaloids isolated from the fruits of Evodia rutaecarpa, on the guinea-pig isolated right atria: Possible involvement of vanilloid receptors

Planta Medica

Volumn 67, Issue 3, 2001, Pages 244-248

  Kobayashi, Y ^a   Hoshikuma, K ^a   Nakano, Y ^a   Yokoo, Y ^a   Kamiya, T ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Capsaicin; Evodia rutaecarpa; Evodiamine; Guinea pig isolated atria; Rutaceae; Rutaecarpine; Vanilloid receptor

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; CAPSAZEPINE; EVODIA FRUIT; EVODIAMINE; PURINE P2X RECEPTOR; QUINAZOLINE DERIVATIVE; RUTAECARPINE; RUTHENIUM RED; VANILLOID RECEPTOR;

ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DOSE RESPONSE; DRUG EFFECT; DRUG ISOLATION; GUINEA PIG; HEART ATRIUM; HEART ATRIUM CONTRACTION; INOTROPISM; MALE; NONHUMAN; PROTEIN SECRETION; TACHYPHYLAXIS;

ALKALOIDS; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CAPSAICIN; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUIT; GUINEA PIGS; HEART ATRIA; HEART RATE; MALE; MYOCARDIAL CONTRACTION; PLANT EXTRACTS; PLATELET AGGREGATION INHIBITORS; PYRIDOXAL PHOSPHATE; QUINAZOLINES; RECEPTORS, DRUG; RECEPTORS, PURINERGIC; ROSALES; RUTHENIUM RED; STIMULATION, CHEMICAL;

ANIMALIA; CAVIA PORCELLUS; EVODIA; EVODIA RUTAECARPA; RUTACEAE; SUS SCROFA;

EID: 0035046155     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2001-12008     Document Type: Article

References (12)

1. The bronchoconstrictive action of evodiamine, an indoloquinazoline alkaloid isolated from the fruits of Evodia rutaecarpa, on guinea-pig isolated bronchus: Possible involvement of vanilloid receptors
2. Effects of capsaicin on nonadrenergic noncholinergic nerves in the guinea pig atria: Role of calcitonin gene-related peptide as cardiac neurotransmitter
3. Role of calcitonin gene-related peptide as cardiotonic neurotransmitter in guinea-pig left atria
4. Effects of calcitonin gene-related peptide (CGRP) and isoproterenol on the contractility and adenylate cyclase activity in the rat heart
5. Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa var. bodinieri (Rutaeceae)
6. Ruthenium red as a capsaicin antagonist
7. The "efferent" function of capsaicin-sensitive nerves: Ruthenium red discriminates between different mechanisms of activation
8. PPADS selectively antagonize P2X-purinoceptor-mediated responses in the rabbit urinary bladder
9. Capsaicin-sensitive sensory-motor neurotransmission in the peripheral control of cardiovascular function
10. One-way cross-desensitization between P2X purinoceptors and vanilloid receptors in adult rat dorsal root ganglion neurons
11. Dual effect of ATP and UTP on rat atria: Which types of receptors are involved?
12. Molecular structures of the indole alkaloids, evodiamine and rutaecarpine, from Evodia fruit