Structure-activity relationship of antioxidants for inhibitors of linoleic acid hydroperoxide-induced toxicity in cultured human umbilical vein endothelial cells

Cytotechnology

Volumn 35, Issue 1, 2001, Pages 43-55

  Kaneko, Takao ^a   Baba, Naomichi ^b   Matsuo, Mitsuyoshi ^c  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c KONAN UNIVERSITY   (Japan)

Author keywords

Antioxidant; Cytotoxicity; Human umbilical vein endothelial cell; Linoleic acid hydroperoxide

Indexed keywords

6 HYDROXY 2,2,5,7,8 PENTAMETHYLCHROMAN; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BAICALEIN; BUTYLCRESOL; CATECHIN; CELL PROTECTION; CYTOTOXICITY; HYDROPEROXIDE DERIVATIVE; LINOLEIC ACID; LUTEOLIN; PROBUCOL; STRUCTURE ACTIVITY RELATION; TROLOX C;

EID: 0035045742     PISSN: 09209069     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008139412588     Document Type: Conference Paper

References (60)

1. Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation
2. Flavonoids as antioxidants: Determination of radical-scavenging efficiencies
3. Radical chemistry of flavonoid antioxidants
4. Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human plasma and erythrocyte membrane?
5. Autoxidation of biological molecules. 4. Maximizing the antioxidants activity of phenols
6. Vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q, b-carotene, canthaxanthin, and (+)-catechin protect against oxidative damage to kidney, heart, lung and spleen
7. Protection by multiple antioxidants against lipid peroxidation in rat liver homogenate
8. Inhibitory effects of phenolic compounds on CCI4-induced microsomal lipid peroxidation
9. Scavenger and antioxidant properties of ten synthetic flavones
10. Effect of various flavonoids on lysosomes subjected to an oxidative or an osmotic stress
11. The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds
12. Lipid peroxidation: Part II pathological implications
13. Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminescence
14. (-)-Epigallocatechin gallate. Green tea polyphenols, anticarcinogens and antioxidants
15. ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers
16. The correlation between active oxygen scavenging and antioxidative effects of flavonoids
17. Flavonoids, a class of natural products of high pharmacological potency
18. Effect of plant phenolics on the formation of the spin-adduct of hydroxyl radical and the DNA strand breaking by hydroxyl radical
19. Lipid peroxidation and mechanisms of toxicity
20. Flavonoids as antioxidants
21. Isomerization of linoleic acid hydroperoxides under argon and under degassed condition
22. Lethal effects of a linoleic acid hydroperoxide and its autoxidation products, unsaturated aliphatic aldehydes, on human diploid fibroblasts
23. Cytotoxicities of a linoleic acid hydroperoxide and its related aliphatic aldehydes toward cultured human umbilical vein endothelial cells
24. Protective effect of vitamin E on linoleic acid hydroperoxide-induced injury to human endothelial cells
25. Protective effect of lipophilic derivatives of ascorbic acid on lipid peroxide-induced endothelial injury
26. Phospholipid hydroperoxides are significantly less toxic to cultured endothelial cells than fatty acid hydroperoxides
27. Protection of linoleic acid hydroperoxide-induced cytotoxicity by phenolic antioxidants
28. Cytotoxicity of phosphatidylcholine hydroperoxides is exerted through decomposition of fatty acid hydroperoxide moiety
29. Inhibition of linoleic acid hydroperoxide-induced toxicity in cultured human umbilical vein endothelial cells by catechins
30. Protective effect of flavonoids on endothelial cells against linoleic acid hydroperoxide-induced toxicity
31. Enzymatic synthesis of two stable (-)-epigallocatechin gallate-glucosides by sucrose phosphorylase
32. Purification of two distinct growth factors from bovine neutral tissue by heparin affinity chromatography
33. Structure of ascorbic acid and its biological function. Determination of the conformation of ascorbic acid and isoascorbic acid by infrared and ultraviolet investigations
34. Effects of the antioxldant (6,7-dihydroxycoumarin) esculetin on the glutathione system and lipid peroxidation in mice
35. Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation
36. A kinetic study of reactions of tocopherols with a substituted phenoxyl radicals
37. Suppression of active oxygen-induced cytotoxicity by flavonoids
38. Suppression of hydroperoxide-induced cytotoxicity by polyphenols
39. Antioxidants/antimutagens in foods
40. Ultraviolet-treated lipoproteins as a model system for the study of the biological effects of lipid peroxides on cultured cells. III. The protective effect of antioxidants (probucol, catechin, vitamin E) against the cytotoxicity of oxidized LDL occurs in two different ways
41. Quercetin prevents the cytotoxicity of oxidized LDL on lymphoid cells lines
42. Synthesis of methyl substituted 6-hydroxychromans, model compounds of tocopherols
43. Studies on the activities of tannins and related compounds from medicinal plants and drugs. I. Inhibitory effects on lipid peroxidation in mitochondria and microsomes of liver
44. Interactions of a series of coumarins with reactive oxygen species
45. Effects of coumarin derivatives on superoxide anion generation
46. Effects of flavonoids on nonenzymatic lipid peroxidation: Structure-activity relationship
47. The pathogenesis of atherosclerosis: A perspective for the 1990s
48. Injury to cultured endothelial cells from human umbilical vein by linoleic acid hydroperoxide
49. Intestinal absorption of luteolin and luteolin 7-O-b-glucoside in rats and humans
50. -
51. Oxidation of lipids. XIV. Inhibition of oxidation of methyl linoleate by fatty acid esters of L-ascorbic acid
52. Will antioxidant nutrients slow aging processes?
53. Protective effect of epicatechin, epicatechin gallate, and quereetin on lipid peroxidation in phospholipid bilayers
54. Antioxidant activity of flavonoids and reactivity with peroxy radical
55. Antioxidant activity of flavonoids and reactivity with peroxy radical
56. Structural aspects of antioxidant activity of flavonoids
57. Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells
58. Inhibition of tobacco-specific nitrosoamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenols as antioxidants
59. Antitumor promoting activity of (-)-epigallocatechin gallate, the main constituent of 'tannin' in green tea
60. Phenolic compounds and an analog as superoxide anion scavengers and antioxidants