Leukodepletion and aprotinin improve clinical outcome after extracorporeal circulation

Perfusion

Volumn 16, Issue SUPPL., 2001, Pages 5-9

  Gott, J P ^a  

^a PIEDMONT HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; APROTININ; CORTICOSTEROID; HEPARIN; METHYLPREDNISOLONE;

ARTICLE; BLOOD AUTOTRANSFUSION; BLOOD FILTRATION; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CLINICAL TRIAL; COMPLEMENT ACTIVATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST CONTROL; ECONOMIC ASPECT; EXTRACORPOREAL CIRCULATION; HEALTH CARE COST; HEALTH CARE QUALITY; HEART SURGERY; HUMAN; HUMAN CELL; LEUKOCYTE; LEUKOPENIA; MAJOR CLINICAL STUDY; MORBIDITY; MORTALITY; PHARMACOLOGICAL PROCEDURES; PREDICTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TREATMENT OUTCOME; BLOOD TRANSFUSION; CENTRIFUGAL PUMP; DEPLETION; HEMATOLOGIC DISEASE; HEMATOLOGICAL PROCEDURE; HOSPITALIZATION COST; KIDNEY DYSFUNCTION; LENGTH OF STAY; LEUKODEPLETION; MEMBRANE OXYGENATOR; ROLLER PUMP;

EID: 0035045331     PISSN: 02676591     EISSN: None     Source Type: Journal    
DOI: 10.1177/026765910101600i102     Document Type: Article

References (27)

1. Beneficial effects of leukocyte depletion of transfused blood on postoperative complications in patients undergoing cardiac surgery: A randomized clinical trial
2. Prospects for understanding and eliminating the deleterious effects of cardiopulmonary bypass
3. Modifying risk for extracorporeal circulation: Trial of four antiinflammatory strategies
4. ACC/AHA Guidelines for coronary artery bypass graft surgery
5. Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass-induced inflammation in humans
6. Clinical considerations in the use of corticosteroids [special article]
7. Pretreatment with corticosteroids to alleviate allergic reactions to intravenous contrast material
8. A multicenter, double-blind, placebo-controlled trial of aprotinin for reducing blood loss and the requirement for donor-blood transfusion in patients undergoing repeat coronary artery bypass grafting
9. Aprotinin therapy for reoperative myocardial revascularization: A randomized double-blinded, placebo-controlled study
10. An antiinflammatory property of aprotinin detected at the level of leukocyte extravasation
11. Cardiopulmonary bypass and the inflammatory response: A role for serine protease inhibitors?
12. Use of heparin-coated cardiopulmonary bypass
13. Heparin-coated circuits reduce the inflammatory response to cardiopulmonary bypass
14. Heparin-coated bypass circuits reduce pulmonary injury
15. Heparin-coated cardiopulmonary bypass circuits: Hemostatic alterations and postoperative blood loss
16. Surface-bound heparin - Panacea or peril?
17. Homologous blood transfusion as a risk factor for postoperative infection after coronary artery bypass graft operations
18. Randomised comparison of leucocyte-depleted versus buffy-coat-poor blood transfusion and complications after colorectal surgery
19. Temporary leukocyte depletion reduces ventricular dysfunction during prolonged postischemic reperfusion
20. Transfusion-induced immunomodulation and its clinical consequences
21. Role of leukocyte depletion during cardiopulmonary bypass and cardioplegic arrest
22. Leukocyte-depleted reperfusion of transplanted human hearts: A randomized, double-blind clinical trial
23. Controlled reperfusion of the regionally ischemic myocardium with leukocyte-depleted blood reduces stunning, the no-reflow phenomenon, and infarct size
24. Evaluation of leukocyte-depleted terminal blood cardioplegic solution in patients undergoing elective and emergency coronary artery bypass grafting
25. Leukocyte depletion results in improved lung function and reduced inflammatory response after cardiac surgery
26. Leukocyte depletion ameliorates free radical-mediated lung injury after cardiopulmonary bypass
27. Depletion of neutrophils by filter during aortocoronary bypass surgery transiently improves postoperative cardiorespiratory status