Pharmacodynamic and pharmacokinetic properties of a premixed 85/15 human insulin preparation

Clinical Therapeutics

Volumn 23, Issue 3, 2001, Pages 404-412

  Mudaliar, Sunder Raj D ^a   Mohideen, Pharis ^a   Baxi, Sunita C ^a   Joyce, Mary ^a   Armstrong, Debra A ^a   Strange, Poul ^b   Henry, Robert R ^a  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b NOVO NORDISK INC   (United States)

Author keywords

Diabetes; Euglycemic clamp; Insulin; Pharmacodynamics; Pharmacokinetics; Premixed insulin

Indexed keywords

GLUCOSE; HUMAN INSULIN; INSULIN; ISOPHANE INSULIN; NOVOLIN 70 30; NOVOLIN 85 15; PENFILL;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CROSSOVER PROCEDURE; DIABETES MELLITUS; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; DRUG INDUCED DISEASE; DRUG SAFETY; GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INJECTION; INSULIN BLOOD LEVEL; INSULIN TREATMENT; MALE; NORMAL HUMAN;

EID: 0035045151     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(01)80045-X     Document Type: Article

References (10)

1. Premixed insulins: How do they compare with other insulin preparations?
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4. Premixed vs. self-mixed insulin in the treatment of type 2 diabetes mellitus: A randomized trial
5. Glucose clamp technique: A method for quantifying insulin secretion and resistance
6. Assessment of insulin sensitivity in vivo
7. Pharmacokinetic and pharmacodynamic properties of insulin analog NN304 in comparison to NPH insulin in humans
8. A comparison of the pharmacokinetics and metabolic effects of human regular and NPH insulin mixtures
9. Premixed insulin at ratio 3/7 and regular + isophane insulins at mixing ratios from 2/8 to 4/6 achieve the same metabolic control
10. Comparative pharmacokinetics and glucodynamics of two human insulin mixtures, 70/30 and 50/50 insulin mixtures