Autonomic regulation of neuroimmunological responses: Implications for multiple sclerosis

Journal of Clinical Immunology

Volumn 21, Issue 2, 2001, Pages 61-73

  Frohman, E M ^a   Monson, N L ^a   Lovett Racke, A E ^a   Racke, M K ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Autonomic regulation; Multiple sclerosis; Neuroimmunological responses

Indexed keywords

AUTOANTIBODY; BETA ADRENERGIC RECEPTOR; CD4 ANTIGEN; CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN; MYELIN; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR;

ARTICLE; AUTOIMMUNITY; AUTONOMIC INNERVATION; B LYMPHOCYTE; CELL MIGRATION; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; MULTIPLE SCLEROSIS; NEUROIMMUNOLOGY; PRIORITY JOURNAL; T LYMPHOCYTE;

AUTONOMIC NERVOUS SYSTEM; HUMANS; MULTIPLE SCLEROSIS; NEUROIMMUNOMODULATION;

EID: 0035044999     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011016124524     Document Type: Article

References (116)

1. Noradrenergic sympathetic neural interactions with the immune system: Structure and function
2. Catecholamine influences and sympathetic neural modulation of immune responsiveness
3. Suppression of antigen-specific Th2 cell-dependent IgM and IgG1 production following norepinephrine depletion in vivo
4. Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology
5. Functional IL-4 receptors on mouse astrocytes: IL- 4 inhibits astrocyte activation and induces NGF secretion
6. Developmentally regulated gene expression of Th2 cytokines in the brain
7. Differential expression of the beta2-adrenergic receptor by Th1 and Th2 clones: Implications for cytokine production and B cell help
8. Activated T helper 1 and T helper 2 cells differentially express the beta-2-adrenergic receptor: A mechanism for selective modulation oft helper 1 cell cytokine production
9. Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system
10. Role of nerve growth factor in experimental autoimmune encepahlomyelitis
11. Neural immunoregulation: Emerging roles for nerves in immune homeostasis and disease
12. The sympathetic nervous system modulates antibody response to thymus-independent antigens
13. β-adrenergic receptors on splenic lymphocytes from axotomized mice
14. Chemical sympathectomy augments the severity of experimental allergic encephalomyelitis
15. The β-adrenergic agonist isoproterenol suppresses experimental allergic encephalomyelitis in Lewis rats
16. Activation of antigen-specific CD4+ Th2 cells and B cells in vivo increases norepinephrine release in the spleen and bone marrow
17. Dynamic norepinephrine alterations in bone marrow: Evidence of functional innervation
18. Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones
19. Nerve growth factor production by lymphocytes
20. Expression of β-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs
21. NGF modulates sympathetic innervation of lymphoid tissues
22. Beta-adrenergic receptors in human leukocyte subpopulations
23. Beta-adrenergic receptors on murine lymphocytes: Density varies with cell maturity and lymphocyte subtype and is decreased after antigen administration
24. Changes in beta-adrenergic receptor distribution on immunocytes during differentiation: An analysis of T cells and macrophages
25. Evidence implicating utilization of different T cell receptor-associated signaling pathways by Th-1 and Th-2 clones
26. cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells
27. Beta-adrenoreceptor-mediated inhibition of IFN-gamma. IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype
28. Beta2-agonists prevent Th 1 development by selective inhibition of interleukin 12
29. Sympathetic skin responses are decreased and lymphocyte beta-adrenergic receptors are increased in progressive multiple sclerosis
30. Increased lymphocyte beta-adrenergic receptor density in pro gressive multiple sclerosis is specific for the CD8+, CD28-suppressor cells
31. Impaired sympathetic influence on the immune response in patients with rheumatoid arthritis due to lymphocyte subset-specific modulation of beta 2-adrenergic receptors
32. The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: Mechanism of action
33. Interleukin-4 (IL-4), interferon-γ, and interleukin-5 (IL-5) in peripheral blood of children with atopic asthma
34. Allergen challenge primes IL-5 mRNA production and abrogates beta-adrenergic function in peripheral blood T lymphocytes from asthmatics
35. Beta adrenergic receptors in lymphocyte subpopulations
36. Norepinephrine and the antibody response
37. Distrubution of beta-adrenergic receptors on human lymphocyte subpopulations
38. Beta-adrenergic receptors are different in subpopulations of human circulating lymphocytes
39. Interleukin-2: Molecular and clinical aspects
40. Distinctions in lymphocyte responses to IL-2 and IL-15 reflect differential ligand binding interactions with the IL-2R beta chain and suggest differential roles for the IL-2R alpha and IL-15R alpha subunits
41. Reduced responsiveness of adenylate cyclase to forskolin in human lymphoma cells
42. Differences in beta-adrenergic receptor density and adenylate cyclase activity between normal and leukaemic leukocytes
43. Stimulation of the B cell receptor, CD86 (B7-2) and the β-adrenergic receptor intrinsically modulates the level of IgG1 and IgE produced per B cell
44. T and B lymphocytes reacting with the extracellular loop of the β-adrenergic receptor are present in the peripheral blood of patients with myasthenia gravis
45. Differential regulation of mouse B-cell activation by beta-adrenoceptor stimulation depending on type of mitogens
46. Neural and endogenous catecholamines in the bone marrow. Circadian association of norepinephrine with hematopoiesis?
47. A chemokine-driven positive feedback loop organizes lymphoid follicles
48. The biology of chemokines and their receptors
49. Norepinephrine inhibits gamma-interferon-induced MHC class II (Ia) antigen expression on cultured brain astrocytes
50. Norepinephrine inhibits interferon-induced major histocompatibility class II (Ia) antigen expression on cultured astrocytes via beta2-adrenergic signal transduction mechanisms
51. L-Deprenyl-induced increase in IL-2 and NK cell activity accompanies restoration of nonadrenergic nerve fibers in the spleens of old F344 rats
52. Effects of L-deprenyl treatment on noradrenergic innervation and immunae reactivity in lymphoid organs of young F344 rats
53. Nerve growth factor is an autocrine survival factor for memory B lymphocytes
54. Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma
55. Nerve growth factor specifically induces human IgG4 production
56. Nerve growth factor induces growth and differentiation of human B lymphocytes
57. Nerve growth factor inhibits immunoglobulin production by but not proliferation of human plasma cell lines
58. Comparative study of nerve growth factor and anti-CD40 antibody effects on Ig secretion and signal transduction pathways
59. Functional nerve growth factor receptors on human B lymphocytes
60. The role of B cells and autoantibodies in multiple sclerosis
61. Ig lambda and heavy chain usage in early untreated systemic lupus erythematosus suggests intensive B cell stimulation
62. Rheumatoid arthritis synovial stromal cells inhibit apoptosis and up-regulate Bcl-XL expression by B cells in a CD49/CD29-CD106-dependent mechanism
63. Nerve growth factor signal transduction in human B lymphocytes is mediated by gp 140
64. Activation of Vav and Ras through the nerve growth factor and B cell receptors by different kinases
65. Nerve growth factor induces activation of MAP-kinase and p90 in human B lymphocytes
66. Regulation of immunoglobulin production by nerve growth factor: Comparison with anti-CD40
67. Nerve growth factor and anti-CD40 provide opposite signals for the production of IgE in intedeukin-4-treated lymphocytes
68. A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas
69. An acidic protein isolated from fibrous astrocytes
70. Guidance of neurons migrating to the fetal monkey neocortex
71. Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A golgi and electron microscopic study in macacus rhesus
72. Astroglial cell contributions to neuronal survival and neuritic growth
73. Molecular specialization of astrocyte processes at nodes of Ranvier in rat optic nerve
74. Neuronal-glial interactions
75. Role of astrocytes in compartmentalization of amino acid and energy metabolism
76. Functional receptors for neurotransmitters on astroglial cells
77. Gliosis following CNS injury: The anatomy of astrocytic scars and their influences on axonal elongation
78. Astrocytes and intracerebral immune responses
79. Axonal transection in the lesions of multiple sclerosis
80. MS Histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy
81. Indictment of the microglia as the villain in multiple sclerosis
82. In vivo immunomodulation by monoclonal anti-CD 4 antibody. II. Effect on T cell response to myelin basic protein and experimental allergic encephalomyelitis
83. Multiple sclerosis and its animal models: The role of the major histocompatibility complex and the T cell receptor repertoire
84. TNF alpha expression by resident microglial and infiltrating leukocytes in the central nervous system of mice with EAE
85. Suppression of EAE in Lewis rats after elimination of macrophages
86. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
87. The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-γ, tumor necrosis factor α, lymphotoxin, and interleukin-1: Relevance to intracerebral antigen presentation
88. Astrocytes as mediators of immune and inflammatory responses in the CNS
89. Molecular biology of glia:astrocytes
90. Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalogenic T cells by IFN-γ-activated SJL/J astrocytes
91. IFN-γ-activated primary murine astrocytes express B7 costimulatory molecules and prime naïve antigen-specific T cells
92. Interferon-gamma and Ia antigen are present on astrocytes in active chronic multiple sclerosis lesions
93. Multiple sclerosis: A role for astroglia in active demyelination suggested by class II MHC expression and ultrastructural study
94. Astrocyte expression of major histocompatibility complex gene products in multiple sclerosis brain tissue obtained by stereotactic biopsy
95. Astrocytes in multiple sclerosis lack beta-2 adrenergic receptors
96. Regulation of adrenergic receptor function by phosphorylation
97. Production of prostaglandin E and interleukin 1-like factors by cultures of astrocytes and C-6 glioma cells
98. Receptors regulating the level of cyclic AMP in primary cultures of perinatal mouse brain
99. Analysis of Ia induction of Lewis rat astrocytes in vitro by virus particles and bacterial adjuvants
100. Prazosin an alpha-1-adrenergic receptor antagonist, suppresses experimental autoimmune encephalomyelitis in the Lewis rat
101. Inducible expression of H-2 and Ia antigens on brain cells
102. Activation of muscarinic and of alpha-1-adrenergic receptors on astrocytes results in the accumulation of inositol phosphates
103. Glutamate differentially inhibits the expression of class II MHC antigens on astrocytes and microglia
104. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains
105. Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures
106. Induction of nitric oxide synthase activity in human astrocytes by interleukin-1-beta and interferon-gamma
107. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages
108. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin
109. Cytokine expression in the brain during the acquired immunodeficiency syndrome
110. Interleukin-1 of the central nervous system is produced by ameboid microglia
111. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
112. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide
113. Canine distemper virus-specific antibodies in multiple sclerosis
114. Astrocytic infection in canine distemper virus-induced demyelination
115. Persistent paramyxovirus infections and behavior of beta-adrenergic receptors in C-rat glioma cells