A comparison of the efficacy and tolerability of titrate-to-goal regimens of simvastatin and fluvastatin: A randomized, double-blind study in adult patients at moderate to high risk for cardiovascular disease

Clinical Therapeutics

Volumn 23, Issue 3, 2001, Pages 467-478

  Van Dam, Marjel J ^a   Penn, Huub J A M ^b   Den Hartog, Frank R ^c   Kragten, Hans A ^d   Trip, Mieke D ^a   Buirma, Rudolf J A ^e   Kastelein, John J P ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b St Jans Gasthuis ^*  (Netherlands)

^c GELDERSE VALLEI HOSPITAL   (Netherlands)

^d Zuyderland Medical Centre   (Netherlands)

^e NV ORGANON   (Netherlands)

Author keywords

Fluvastatin; HMG CoA reductase inhibitors; Hypercholesterolemia; Simvastatin; Titrate to goal

Indexed keywords

FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HEALTH PROGRAM; HIGH RISK PATIENT; HUMAN; HYPERCHOLESTEROLEMIA; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PARALLEL DESIGN; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK BENEFIT ANALYSIS; RISK FACTOR; SIDE EFFECT; STATISTICAL ANALYSIS; TITRIMETRY;

EID: 0035044920     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(01)80050-3     Document Type: Article

References (18)

1. Predisposition to atherosclerosis in the head, heart, and legs. The Framingham Study
2. Cholesterol reduction and its impact on coronary artery disease and total mortality
3. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
4. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
5. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
6. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS
7. Behandeling en preventie van coronaire hartziekten door verlaging van de plasma cholesterol concentratie
8. Expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel II)
9. Prevention of coronary heart disease in clinical practice: Recommendations of the Second Joint Task Force of European and Other Societies on Coronary Prevention
10. A population-based treat-to-target pharmacoeconomic analysis of HMG-CoA reductase inhibitors in hypercholesterolemia
11. Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency
12. Multicentre study of a new enzymatic method of cholesterol determination
13. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide
14. Cholesterol determination in high-density lipoproteins separated by three different methods
15. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
16. Use of serum cholesterol/triglyceride ratio to discern for which individuals the Friedewald formula can be used confidently
17. A model for harmonization of routine clinical chemistry results between clinical laboratories
18. The Virtual Central Laboratory approach for the retrieval and management of clinical laboratory data for clinical studies