Developmentally induced microencephalopathy in guinea pigs -embryonic glial cell activation marks selective neuronal death

International Journal of Developmental Neuroscience

Volumn 19, Issue 3, 2001, Pages 313-318

  Roßner, Steffen ^a   Brückner, Martina K ^a   Bigl, Volker ^a  

^a Paul Flechsig Inst for Brain Res   (Germany)

Author keywords

Alzheimer's disease; Animal model; Astrocytes; c Fos; Gliosis; Guinea pig; Microencephalopathy; Microglia; Neocortex

Indexed keywords

AMYLOID PRECURSOR PROTEIN; METHYLAZOXYMETHANOL ACETATE; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE C;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; BRAIN DEVELOPMENT; BRAIN DISEASE; CELL ACTIVATION; CONFERENCE PAPER; CONTROLLED STUDY; GUINEA PIG; IMMEDIATE EARLY GENE; MICROGLIA; NEOCORTEX; NERVE DEGENERATION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIMETABOLITES; ASTROCYTES; BROMODEOXYURIDINE; CELL DEATH; FEMALE; GENES, IMMEDIATE-EARLY; GUINEA PIGS; METHYLAZOXYMETHANOL ACETATE; MICROGLIA; NEOCORTEX; NEURONS; PREGNANCY; PROTEIN KINASE C; PROTEIN SYNTHESIS INHIBITORS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0035042971     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-5748(01)00015-6     Document Type: Conference Paper

References (41)

1. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
2. Neuronal migration disorders and epilepsy: a morphological analysis of three surgically treated patients
3. Amyloid precursor protein in guinea pigs-complete cDNA sequence and alternative splicing
4. Guinea pig primary cell cultures provide a model to study expression and amyloidogenic processing of endogenous amyloid precursor protein
5. Development of rat visual system after prenatal x-irradiation
6. Differential translocation of protein kinase C isozymes in rats characterized by a chronic lack of LTP induction and cognitive impairment
7. Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C
8. Protein kinase C-dependent phosphorylation in prenatally induced microencephaly
9. Developmental models of brain dysfunctions induced by targeted cellular ablations with methylazoxymethanol
10. Selective in vitro blockade of neuroepithelial cells proliferation by methylazoxymethanol, a molecule capable of inducing long lasting functional impairments
11. Cortical malformations and epilepsy: new insights from animal models
12. Prenatal methylazoxymethanol treatment in rats produces brain abnormalities with morphological similarities to human developmental brain dysgeneses
13. Altered connections between neocortical and heterotopic areas in methylazoxymethanol-treated rat
14. Factors influencing the processing and function of the amyloid beta precursor protein-a potential therapeutic target in Alzheimer's disease
15. Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence
16. Changes in protein kinase C and its presynaptic substrate B-50/GAP-43 after intrauterine exposure to methylazoxymethanol, a treatment inducing cortical and hippocampal damage and cognitive deficit in rats
17. Increased presynaptic protein kinase C activity and glutamate release in rats with prenatally induced hippocampal lesion
18. Carcinogenicity of azoxymethane dependent on age in BD rats
19. Amyloidogenicity of rodent and human βA4 sequences
20. c-Jun and Bax: regulators of programmed cell death in developing neurons
21. A four-layered 'lissencephalic' cortex induced by prenatal x-irradiation in the rat
22. The role of the phosphoinositide signalling system in the pathogenesis of sporadic Alzheimer's disease: a hypothesis
23. Neurotrophins require distinct extracellular signals to promote the survival of CNS neurons in vitro
24. Microglia in experimental neuropathology
25. Is the guinea-pig a rodent?
26. Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system
27. Histological and neurochemical effects of fetal treatment with methylazoxymethanol on rat neocortex in adulthood
28. Cytotoxic lesions and the development of transmitter systems
29. Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain raections
30. Regulation of amyloid precursor protein (APP) secretion by protein kinase Cα in human ntera 2 neurons (NT2N)
31. Microglia: a sensor for pathological events in the CNS
32. Expression of c-fos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra
33. Is Fos protein expressed by dying striatal neurons after immature hypoxic-ischemic brain injury?
34. Expression of fos-related antigen-2 in rat hippocampus after middle cerebral arterial occlusion
35. Selective induction of c-Jun and NGF in reactive astrocytes after cholinergic degenerations in rat basal forebrain
36. Constitutive overexpression of protein kinase C in guinea pig brain increases α-secretory APP processing without decreasing β-amyloid generation
37. Microglial-neuronal interactions
38. Brain-derived neurotrophic factor (BDNF) protects cultured rat cerebellar granule neurons against glucose deprivation-induced apoptosis