Catechol-O-methyltransferase inhibitors in the management of parkinson's disease

Seminars in Neurology

Volumn 21, Issue 1, 2001, Pages 15-22

  Hanson, M R ^a   Galvez Jimenez N ^a  

^a DEPARTMENT OF COLORECTAL SURGERY   (United States)

Author keywords

COMT inhibitors; Entacapone; Tolcapone

Indexed keywords

3 O METHYLDOPA; BENSERAZIDE; CARBIDOPA; CATECHOL METHYLTRANSFERASE INHIBITOR; DECARBOXYLASE INHIBITOR; DOPAMINE RECEPTOR STIMULATING AGENT; ENTACAPONE; LEVODOPA; NITECAPONE; TOLCAPONE;

DRUG EFFECT; DRUG EFFICACY; DYSKINESIA; ENZYME ACTIVITY; ENZYME INHIBITION; GASTROINTESTINAL SYMPTOM; HUMAN; MOTOR DYSFUNCTION; NEUROLOGICAL COMPLICATION; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW;

EID: 0035040644     PISSN: 02718235     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2001-13115     Document Type: Review

References (20)

1. PET: Its clinical role in neurology
2. Biochemical aspects of Parkinson's disease
3. Success and problems of long-term levodopa therapy in Parldnson's disease
4. Levodopa: Pharmacology, pharmacokinetics and pharmacodynamics
5. Complications associated with chronic levodopa therapy in Parkinson's disease
6. General properties and clinical possibilities of new selective inhibitors of catechol-O-methyltransferase
7. Improved therapy of Parkinson's disease with tolcapone and central COMT inhibitors with a S-adenosyl-L-methionine sparing effect
8. Extending levodopa action: COMT inhibition
9. Potent COMT inhibition by RO40-7592 in the periphery and in the brain: Preclinical and clinical findings
10. Pharmacokinetics, pharmacodynamics and tolerability of tolcapone: A review of early studies in volunteers
11. Tolcapone in stable Parkinson's disease: Efficacy and safety of long term treatment
12. Tolcapone improves motor fluctuation in parkinsonian patients with the "wearing-off" phenomena
13. The effect of catechol-O-methyltransferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers
14. Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations
15. Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations
16. Entacapone improves motor fluctuations in levodopa treated Parkinson's disease patients
17. COMT inhibition: A new treatment strategy for Parkinson's disease
18. Influence of COMT inhibition on levodopa pharmacology and therapy
19. Interventions to achieve tonic exposure to levodopa: Delaying or preventing the onset of motor complications
20. Catechol-o-methyltransferase inhibition with tolcapone reduces the "wearing off" phenomena and levodopa requirement in fluctuating parkinsonian patients