Antinociceptive effect of U-50488H, a κ-opioid agonist, in streptozotocin-induced diabetic mice

Journal of Pharmacy and Pharmacology

Volumn 53, Issue 4, 2001, Pages 521-526

  Suzuki, Y ^a   Goto, K ^a   Shiizaki, K ^a   Omiya, Y ^a   Ishige, A ^a   Komatsu, Y ^a   Kamei, J ^b  

^a TSUMURA AND CO   (Japan)

^b HOSHI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; CHOLECYSTOKININ; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; CHOLECYSTOKININ RECEPTOR STIMULATING AGENT; DESULFOCHOLECYSTOKININ OCTAPEPTIDE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; PD 135158;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MEGADOSE; DRUG POTENCY; DRUG POTENTIATION; MALE; MOUSE; NONHUMAN; RECEPTOR INTRINSIC ACTIVITY; STREPTOZOCIN DIABETES;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESICS; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-BACTERIAL AGENTS; CHOLECYSTOKININ; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; PAIN; STREPTOZOCIN;

EID: 0035040158     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357011775622     Document Type: Article

References (20)

1. Mechanical hyperalgesia in streptozotocin-diabetic rats
2. Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics
3. Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain
4. Endogenous opioid immunoreactivity in rat spinal cord following traumatic injury
5. Pharmacological effects produced by intracerebral injections of drugs in the conscious mouse
6. Intrathecal morphine in mice: A new technique
7. Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: Stimulus specificity, behavioral parameters and opioid receptor binding
8. Dynorphin increases in the dorsal spinal cord in rats with a painful peripheral neuropathy
9. Streptozotocin-induced diabetes in mice reduces the nociceptive threshold, as recognized after application of noxious mechanical stimuli but not of thermal stimuli
10. Streptozotocin-induced diabetes selectively alters the potency of analgesia produced by μ-opioid agonists, but not by δ- and κ-opioid agonists
11. Role of spleen or spleen products in the deficiency in morphine-induced analgesia in diabetic mice
12. 2-opioid receptors
13. Evidence for differential modulation of μ-opioid receptor-mediated antinociception and antitussive activities by spleen-derived factor(s) from diabetic mice
14. 2-opioid receptors
15. Traumatic injury alters opiate receptor binding in rat spinal cord
16. Glycemic control of pain threshold in diabetic and control rats
17. Narcotics and diabetes. I. The effects of streptozotocin-induced diabetes on the antinociceptive potency of morphine
18. Antinociceptive effect of Gosha-jinki-gan, a Kampo medicine, in streptozotocin-induced diabetic mice
19. Differentiation of acupuncture and nonacupuncture points by difference of associated opioids in the spinal cord in production of analgesia by acupuncture and nonacupuncture point stimulation, and relations between sodium and those opioids
20. Analgesia inhibitory system involvement in nonacupuncture point-stimulation-produced analgesia