Perturbation of the tight junction permeability barrier by occludin loop peptides activates β-catenin/TCF/LEF-mediated transcription

EMBO Reports

Volumn 2, Issue 4, 2001, Pages 306-312

  Vietor, Ilja ^a   Bader, Thomas ^a,b   Paiha, Karin ^a   Huber, Lukas A ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b Institut de Recherche Jouveinal   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DNA; MYC PROTEIN; OCCLUDIN; RNA; SYNTHETIC PEPTIDE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; ASSAY; BREAST EPITHELIUM; CARCINOGENESIS; CELL ADHESION; CELL AGGREGATION; CELL JUNCTION; CELL POLARITY; CELL TRANSFORMATION; CONTROLLED STUDY; CROSS LINKING; DNA FLANKING REGION; GENE CONSTRUCT; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; ONCOGENE C MYC; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN DOMAIN; REPORTER GENE; TIGHT JUNCTION;

ANIMALS; BETA CATENIN; BLOTTING, NORTHERN; CADHERINS; CELLS, CULTURED; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; EPITHELIUM; FEMALE; GENES, MYC; LUCIFERASES; LYMPHOID ENHANCER-BINDING FACTOR 1; MAMMARY GLANDS, ANIMAL; MEMBRANE PROTEINS; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; PEPTIDES; RNA; RNA, MESSENGER; TIGHT JUNCTIONS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; UP-REGULATION;

EID: 0035038783     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kve066     Document Type: Article

References (20)

1. The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression
2. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apicalbasolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein
3. Multiple domains of occludin are involved in the regulation of paracellular permeability
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5. The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions
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7. Occludin: A novel integral membrane protein localizing at tight junctions
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10. Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with β-catenin
11. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma
12. Small synthetic peptides homologous to segments of the first external loop of occludin impair tight junction resealing
13. Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin
14. Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton
15. Cellular junctions in a spectrum of human malignant tumors
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17. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
18. A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier
19. Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia
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